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Books > Medicine > General issues > Medical equipment & techniques > Medical research

Aphasia, Volume 185 (Hardcover): Argye Elizabeth Hillis, Julius Fridriksson Aphasia, Volume 185 (Hardcover)
Argye Elizabeth Hillis, Julius Fridriksson
R5,627 Discovery Miles 56 270 Ships in 12 - 17 working days

Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

Chemical Information Mining - Facilitating Literature-Based Discovery (Paperback): Debra L. Banville Chemical Information Mining - Facilitating Literature-Based Discovery (Paperback)
Debra L. Banville
R1,850 Discovery Miles 18 500 Ships in 12 - 17 working days

The First Book to Describe the Technical and Practical Elements of Chemical Text Mining Explores the development of chemical structure extraction capabilities and how to incorporate these technologies in daily research work For scientific researchers, finding too much information on a subject, not finding enough information, or not being able to access full text documents often costs them time, money, and quality. Addressing these concerns, Chemical Information Mining: Facilitating Literature-Based Discovery presents strategic ideas for properly selecting and successfully using the best text mining tools for scientific research. Links chemical and biological entities at the heart of life science research The book focuses on information extraction issues, highlights available solutions, and underscores the value of these solutions to academic and commercial scientists. After introducing the drivers behind chemical text mining, it discusses chemical semantics. The contributors describe the tools that identify and convert chemical names and images to structure-searchable information. They also explain natural language processing, name entity recognition concepts, and semantic web technologies. Following a section on current trends in the field, the book looks at where information mining approaches fit into the research needs within the life sciences. Shaping the future of scientific information and knowledge management By building knowledge and competency in the growing area of literature-based discovery, this book shows how text mining of the chemical literature can increase drug discovery opportunities and enhance life science research.

Principles and Practices of Lyophilization in Product Development and Manufacturing (Hardcover, 1st ed. 2023): Feroz Jameel Principles and Practices of Lyophilization in Product Development and Manufacturing (Hardcover, 1st ed. 2023)
Feroz Jameel
R4,128 R3,785 Discovery Miles 37 850 Save R343 (8%) Ships in 9 - 15 working days

The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor  - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions.  In addition to other pharmaceuticals and biopharmaceuticals, all these novel formats are fragile with respect to  their stability/structure under processing conditions meaning marginal stability in the liquid state and often require lyophilization to enhance their stability and shelf-life. This book contains chapters/topics that will describe every aspect of the lyophilization process and product development and manufacturing starting from the overview of lyophilization process, equipment required, characterization of the material, design and development of the formulation and lyophilization process, various techniques for characterization of the product, scale-up/tech-transfer and validation.  It also describes the application of CFD coupled with mathematical modeling in the lyophilization process and product development, scale-up, and manufacturing.  Additionally, Principles and Practice of Lyophilization Process and Product Development contains an entire dedicated section on “Preservation of Biologicals†comprised of nine chapters written by experts and including case studies.

Periostin (Hardcover, 1st ed. 2019): Akira Kudo Periostin (Hardcover, 1st ed. 2019)
Akira Kudo
R2,962 Discovery Miles 29 620 Ships in 10 - 15 working days

This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases.

Systematic Approaches to a Successful Literature Review (Hardcover, 3rd Revised edition): Andrew Booth, Anthea Sutton, Mark... Systematic Approaches to a Successful Literature Review (Hardcover, 3rd Revised edition)
Andrew Booth, Anthea Sutton, Mark Clowes, Marrissa Martyn-St James
R3,098 Discovery Miles 30 980 Ships in 12 - 17 working days

Whether you are new to literature reviews or working with new types of data, this book takes the guesswork out of writing your literature review. From deciding how much literature to include to managing your data, assessing your sources, and writing results, it outlines a step-by-step process that works with any data. To help you choose best approach for your research, this book includes: * Worksheets and decision aids to help you plan and organise your literature review * Worked examples and case studies to show you what - and what not - to do in practice * Troubleshooting tips and answers to all your frequently asked questions * Online access to a literature review starter template, an exercise workbook, project diary template, and a source credibility checklist. The perfect project support for any social sciences student, this edition also includes a new chapter on analysing mixed methods research.

Applied Meta-Analysis with R and Stata (Hardcover, 2nd edition): Karl E. Peace, Ding-Geng (Din) Chen Applied Meta-Analysis with R and Stata (Hardcover, 2nd edition)
Karl E. Peace, Ding-Geng (Din) Chen
R3,572 Discovery Miles 35 720 Ships in 9 - 15 working days

Review of the First Edition: The authors strive to reduce theory to a minimum, which makes it a self-learning text that is comprehensible for biologists, physicians, etc. who lack an advanced mathematics background. Unlike in many other textbooks, R is not introduced with meaningless toy examples; instead the reader is taken by the hand and shown around some analyses, graphics, and simulations directly relating to meta-analysis... A useful hands-on guide for practitioners who want to familiarize themselves with the fundamentals of meta-analysis and get started without having to plough through theorems and proofs. -Journal of Applied Statistics Statistical Meta-Analysis with R and Stata, Second Edition provides a thorough presentation of statistical meta-analyses (MA) with step-by-step implementations using R/Stata. The authors develop analysis step by step using appropriate R/Stata functions, which enables readers to gain an understanding of meta-analysis methods and R/Stata implementation so that they can use these two popular software packages to analyze their own meta-data. Each chapter gives examples of real studies compiled from the literature. After presenting the data and necessary background for understanding the applications, various methods for analyzing meta-data are introduced. The authors then develop analysis code using the appropriate R/Stata packages and functions. What's New in the Second Edition: Adds Stata programs along with the R programs for meta-analysis Updates all the statistical meta-analyses with R/Stata programs Covers fixed-effects and random-effects MA, meta-regression, MA with rare-event, and MA-IPD vs MA-SS Adds five new chapters on multivariate MA, publication bias, missing data in MA, MA in evaluating diagnostic accuracy, and network MA Suitable as a graduate-level text for a meta-data analysis course, the book is also a valuable reference for practitioners and biostatisticians (even those with little or no experience in using R or Stata) in public health, medical research, governmental agencies, and the pharmaceutical industry.

Getting Started in Health Research (Paperback): D. Bowers Getting Started in Health Research (Paperback)
D. Bowers
R1,175 Discovery Miles 11 750 Ships in 10 - 15 working days

By the time you've read this book, you'll be ready to design your own research project

Not everyone in clinical research is a scientific investigator. In fact, a large proportion of health professionals undertaking a research project are working in clinical care, as junior doctors, nurses or allied health professionals. For them a book that begins with the basics of study design and takes them through all the stages to data collection, analysis, and submission for publication is vital. "Getting Started in Health Research" is the answer. It provides fundamental information on: Framing the research question Performing the literature search Choosing the study design Collecting data Getting funding Recruiting participants Writing your paper

Lively case studies provide a continuous narrative, addressing the pitfalls and problems that can occur.

Calling upon their vast experience of teaching health research methodology, these authors have turned a seemingly daunting task into a challenging and enjoyable prospect.

"The companion of Understanding Clinical Papers ""www.wiley.com/buy/"9780470091302

Reviews of "Understanding Clinical Papers"

..".an excellent basis for all who intend to write scientific texts as well as those reading, evaluating, and trying to understand the results...""Clinical Chemistry," May 2007

"What makes this book unique is that each point presented is illustrated with excerpts from actual papers, often three or four per chapter...this is a very effective teaching device.""Journal of the American Medical Association," December 26, 2006

"What strikes the reader ... straight away is clarity ... promises to become a recommended text for undergraduate and postgraduate courses.""Journal of Tropical Pediatrics," September 2006

"This book should be an essential addition to the personal libraries of all health care workers . . . ""Oncology," 2002

Traumatic and Ischemic Injury - Methods and Protocols (Hardcover, 1st ed. 2018): Binu Tharakan Traumatic and Ischemic Injury - Methods and Protocols (Hardcover, 1st ed. 2018)
Binu Tharakan
R3,082 R1,779 Discovery Miles 17 790 Save R1,303 (42%) Ships in 12 - 17 working days

This volume focuses on procedures for the development and application of several research animal models and in vitro methods that allow researchers to gain insight into the underlying cellular, biochemical, and physiological mechanisms involved in traumatic and ischemic injury. The chapters in this book discuss topics, such as animal models and techniques commonly used to study traumatic brain injury, hemorrhagic shock, ischemic and hemorrhagic strokes, sepsis, burn injury, hind limb ischemia, myocardial-ischemia-reperfusion injury, intracranial pressure, global hypoxia-induced perinatal seizures models, and in vitro models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Traumatic and Ischemic Injury: Methods and Protocols is a valuable resource for novices with limited experience to help them initiate new research projects, and established researchers to help them identify comparable approaches and strategies to their studies in this field.

Artificial Vision - A Clinical Guide (Hardcover, 1st ed. 2017): Veit Peter Gabel Artificial Vision - A Clinical Guide (Hardcover, 1st ed. 2017)
Veit Peter Gabel
R4,447 Discovery Miles 44 470 Ships in 12 - 17 working days

This book presents and analyses the most recent research dedicated to restoring vision in individuals who are severely impaired or blind from retinal disease or injury. It is written by the leading groups worldwide who are at the forefront of developing artificial vision. The book begins by discussing the difficulties in comparing and interpreting functional results in the area of very low vision and the principal prospects and limitations of spatial resolution with artificial tools. Further on, chapters are included by researchers who stimulate the surface or the pigment epithelial side of the retina and by experts who work on stimulating the optic nerve, the lateral geniculate body and the superficial layers of the visual cortex. Artificial Vision: A Clinical Guide collates the most recent work of key artificial vision research groups to explain in a comparable and stringent order their varying approaches, the clinical or preclinical outcomes and their achievements during the last years. Senior ophthalmic fellows and academic practitioners will find this guide to be an indispensable resource for understanding the current status of artificial vision.

Experiments in Democracy - Human Embryo Research and the Politics of Bioethics (Paperback): Benjamin J. Hurlbut Experiments in Democracy - Human Embryo Research and the Politics of Bioethics (Paperback)
Benjamin J. Hurlbut
R658 Discovery Miles 6 580 Ships in 12 - 17 working days

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences (Hardcover, 1st ed. 2022): Stephen Luby,... The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences (Hardcover, 1st ed. 2022)
Stephen Luby, Dorothy L. Southern
R1,331 R1,261 Discovery Miles 12 610 Save R70 (5%) Ships in 9 - 15 working days

Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade.

Clinical Trial Design - Bayesian and Frequentist Adaptive Methods (Hardcover, New): G. Yin Clinical Trial Design - Bayesian and Frequentist Adaptive Methods (Hardcover, New)
G. Yin
R3,114 Discovery Miles 31 140 Ships in 12 - 17 working days

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods

There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics.

Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include:

Risk and benefit analysis for toxicity and efficacy trade-offs

Bayesian predictive probability trial monitoring

Bayesian adaptive randomization

Late onset toxicity and response

Dose finding in drug combination trials

Targeted therapy designs

The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials.

Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

Theranostics - Methods and Protocols (Paperback, 1st ed. 2019): Jyotsna Batra, Srilakshmi Srinivasan Theranostics - Methods and Protocols (Paperback, 1st ed. 2019)
Jyotsna Batra, Srilakshmi Srinivasan
R3,413 Discovery Miles 34 130 Ships in 10 - 15 working days

This volume explores disease diagnosis and therapy in developing theranostics. The chapters in this book are divided into four parts and cover various techniques used in studying bioengineering, molecular diagnostics, in vivo imaging, and imaging-guided therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Theranostics: Methods and Protocols is a valuable tool for novice and expert clinicians, researchers, and students working in this multidisciplinary field.

Advancements in Clinical Research (Hardcover, 1st ed. 2016): Mieczyslaw Pokorski Advancements in Clinical Research (Hardcover, 1st ed. 2016)
Mieczyslaw Pokorski
R2,896 Discovery Miles 28 960 Ships in 10 - 15 working days

The book presents current progress in clinical practice and research, particularly involving pulmonary diseases. Chapters tackle a variety of topics including a search for potential biomarkers of lung tumors, sleep disordered breathing, neurogenic lung dysfunction, community acquired and nosocomial respiratory infections developing in the chronically ill, mechanisms of hypoxia sensing, and the reasons for frequent visits to primary care facilities causing an ever increasing costs for caregivers and society. Identifying molecular markers expressed in tumors, rather than histological stratification of cancer type, forms a rapidly evolving basis of precision medicine, with the hope of a future development of targeted treatment. Creative ideas drive basic research that spurs innovations that, in turn, when translated into clinical applications, lay the foundation of breakthroughs, hopefully leading to increased longevity and better quality of life. This book is intended for healthcare professionals, particularly pulmonologists, primary care physicians, and other specialists involved in the management of patients.

E-Cell System - Basic Concepts and Applications (Hardcover, 2013 ed.): Satya Nanda Vel Arjunan, Pawan K. Dhar, Masaru Tomita E-Cell System - Basic Concepts and Applications (Hardcover, 2013 ed.)
Satya Nanda Vel Arjunan, Pawan K. Dhar, Masaru Tomita
R4,398 Discovery Miles 43 980 Ships in 10 - 15 working days

The interdisciplinary field of molecular systems biology aims to understand the behavior and mechanisms of biological processes composed of individual molecular components. As we gain more qualitative and quantitative information of complex intracellular processes, biochemical modeling and simulation become indispensable not only to uncover the molecular mechanisms of the processes, but to perform useful predictions. To this end, the E-Cell System, a multi-algorithm, multi-timescale object-oriented simulation platform, can be used to construct predictive virtual biological systems. Gene regulatory and biochemical networks that constitute a sub- or a whole cellular system can be constructed using the E-Cell System to perform qualitative and quantitative analyses. The purpose of E-Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E-Cell System version 3 in terms of the software features and its usage. While the publicly available E-Cell Simulation Environment version 3 User's Manual provides the technical details of model building and scripting, it does not describe some of the underlying concepts of the E-Cell System. The first part of the book addresses this issue by providing the basic concepts of modeling and simulation with the E-Cell System.

Practical Biostatistics - A Step-by-Step Approach for Evidence-Based Medicine (Paperback, 2nd edition): Mendel Suchmacher,... Practical Biostatistics - A Step-by-Step Approach for Evidence-Based Medicine (Paperback, 2nd edition)
Mendel Suchmacher, Mauro Geller
R2,112 Discovery Miles 21 120 Ships in 12 - 17 working days

Practical Biostatistics: A Step-by-Step Approach for Evidence-Based Medicine, Second Edition presents a complete resource of biostatistical knowledge meant for health sciences students, researchers and health care professionals. The book's content covers the investigator's hypothesis, collective health, observational studies, the biostatistics of intervention studies, clinical trials and additional concepts. Chapters are written in a didactic way, making them easier to comprehend by readers with little or no background on statistics. Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision-making using statistical analyses of scientific methods and outcomes to drive further experimentation and diagnosis. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or hands-on guide on how to effectively incorporate biostatistics in clinical trials and research projects.

Nasopharyngeal Carcinoma - Keys for Translational Medicine and Biology (Hardcover, 2013 ed.): Pierre Busson Nasopharyngeal Carcinoma - Keys for Translational Medicine and Biology (Hardcover, 2013 ed.)
Pierre Busson
R4,411 Discovery Miles 44 110 Ships in 10 - 15 working days

This volume intends to contribute to "translational medicine and biology". By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirement for translational research is to establish a multidisciplinary knowledge base shared by the actors of various specialties. This is precisely the aim of the 12 chapters of this book. It will be useful for scientists, including PhD students, who want to become more familiar with the main concepts of NPC pathology, medical imaging and current therapeutics. Conversely, medical doctors who want to update their knowledge of NPC biology will benefit from chapters on viral and cellular oncogenesis and various aspects of host-tumor interactions.

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma (Hardcover): Michael G. Fehlings, Brian Kwon,... Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma (Hardcover)
Michael G. Fehlings, Brian Kwon, Alexander R Vaccaro, F Cumhur Oner
R3,192 Discovery Miles 31 920 Ships in 12 - 17 working days

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.

Structural Genomics on Membrane Proteins (Paperback): Kenneth H. Lundstrom Structural Genomics on Membrane Proteins (Paperback)
Kenneth H. Lundstrom
R1,879 Discovery Miles 18 790 Ships in 12 - 17 working days

While the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins. This discrepancy becomes significantly troublesome when it is coupled with the fact that 60 percent of current drugs are based on targeting this group of proteins, a trend that does not seem likely to reverse. Structural Genomics on Membrane Proteins provides an excellent overview on novel research in bioinformatics and modeling on membranes, as well as the latest technological developments being employed in expression, purification, and crystallography to obtain high-resolution structures on membrane proteins. This cutting-edge work also explains the difficulties facing researchers-both technical and ethical-that have slowed the process. Structural Genomics on Membrane Proteins provides researchers with an unprecedented look at the novel technologies that will ultimately allow them to conquer the last frontier in structural biology, leading to accelerated breakthroughs in drug discovery.

Informatics In Proteomics (Paperback): Sudhir Srivastava Informatics In Proteomics (Paperback)
Sudhir Srivastava
R1,887 Discovery Miles 18 870 Ships in 12 - 17 working days

The handling and analysis of data generated by proteomics investigations represent a challenge for computer scientists, biostatisticians, and biologists to develop tools for storing, retrieving, visualizing, and analyzing genomic data. Informatics in Proteomics examines the ongoing advances in the application of bioinformatics to proteomics research and analysis. Through computer simulations, scientists can determine more about how diseases affect cells, predict how various drug interventions would work, and ultimately use proteins as therapeutic targets. This book first addresses the infrastructure needed for public protein databases. It discusses information management systems and user interfaces for storage, retrieval, and visualization of the data as well as issues surrounding data standardization and integration of protein sequences recorded in the last two decades. The authors subsequently examine the application of statistical and bioinformatic tools to data analysis, data presentation, and data mining. They discuss the implementation of algorithms, statistical methods, and computer applications that facilitate pattern recognition and biomarker discovery by integrating data from multiple sources. This book offers a well-rounded resource of informatic approaches to data storage, retrieval, and protein analysis as well as application-specific bioinformatic tools that can be used in disease detection, diagnosis, and treatment. Informatics in Proteomics captures the current state-of-the-art and provides a valuable foundation for future directions.

Research for the Psychotherapist - From Science to Practice (Hardcover, 2nd edition): Jay L. Lebow, Paul H. Jenkins Research for the Psychotherapist - From Science to Practice (Hardcover, 2nd edition)
Jay L. Lebow, Paul H. Jenkins
R3,927 Discovery Miles 39 270 Ships in 12 - 17 working days

While empirical, scientific research has much to offer to the practice-oriented therapist in training, it is often difficult to effectively engage the trainee, beginning practitioner, or graduate student in the subject of research. This fully revised and expanded edition of Research for the Psychotherapist is an engaging, accessible guide that bridges the gap between gathering, analyzing, presenting, and discussing research and incorporating that research into practice. The authors present concise chapters that distill research findings and clearly apply them to practical issues, while also helping readers progress as consumers of relevant research.

Laboratory Animal Anaesthesia and Analgesia (Paperback, 5th edition): Paul Flecknell Laboratory Animal Anaesthesia and Analgesia (Paperback, 5th edition)
Paul Flecknell
R2,427 Discovery Miles 24 270 Ships in 12 - 17 working days

Laboratory Animal Anaesthesia and Analgesia, Fifth Edition provides a basic guide to anesthesia for a very diverse audience involved in animal testing. This has been the go-to resource for current, clear and evidence-based information for over 30 years. The book is divided into four parts that deal with preparation for anesthesia, including definitions, equipment, preparations, anesthetic and analgesic agents, the management and monitoring of anesthesia, including pre-procedural preparations, monitoring and problems and emergencies through the procedure, advanced and specialized techniques, and analgesia and post-operative care, including recovery and the prevention and management of post-operative pain. Final sections cover anesthesia in common laboratory species, specifically: rodents, rabbits, cats, dogs, ferrets, pigs, sheep and goats, primates, reptiles, amphibians and new specific chapters on birds, fish and cephalopods. This edition keeps up with the tradition of bringing a balanced dose of practical advice, foundational content, and current, updated references, drugs and procedures to veterinarians, technicians, researchers and ethics committee personnel.

Progranulin and Central Nervous System Disorders (Hardcover, 1st ed. 2019): Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura,... Progranulin and Central Nervous System Disorders (Hardcover, 1st ed. 2019)
Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara
R4,639 Discovery Miles 46 390 Ships in 10 - 15 working days

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Pharmacovigilance - Critique and Ways Forward (Hardcover, 1st ed. 2017): I. Ralph Edwards, Marie Lindquist Pharmacovigilance - Critique and Ways Forward (Hardcover, 1st ed. 2017)
I. Ralph Edwards, Marie Lindquist
R4,257 R3,595 Discovery Miles 35 950 Save R662 (16%) Ships in 12 - 17 working days

Written by experienced authors, this book offers expert personal views on what the current problems in pharmacovigilance are and how they should be solved. This book stems from thoughts and ideas discussed in a series of meetings of the International Society of Pharmacovigilance (ISoP), where concerns were raised that the current pharmacovigilance system is not delivering optimally to improve therapeutics in clinical practice. Pharmacovigilance of the future must be an active and integral part of health care delivery, and focus more on science and practices that support health professionals and patients in day-to-day care situations. To achieve this, a dynamic and sustainable development of vigilance must take precedence over the current excessive preoccupations with data processing and regulations; all aspects of medicines use and their effects need to be considered; and all stakeholders must be involved and engaged in an open and constructive debate. The work is essential reading for anyone who has an interest in safer use of medicines. It is intended to be equally challenging and rewarding, and sets out to stimulate a continuous debate on how pharmacovigilance can better meet the needs of health professionals and patients to achieve the aim of wise therapeutic decision making.

Epigenetics - A Different Way of Looking at Genetics (Hardcover, 1st ed. 2016): Walter Doerfler, Petra Boehm Epigenetics - A Different Way of Looking at Genetics (Hardcover, 1st ed. 2016)
Walter Doerfler, Petra Boehm
R4,477 R3,683 Discovery Miles 36 830 Save R794 (18%) Ships in 12 - 17 working days

This book presents epigenetics research as a new way of looking at genetics. Topics range from basic epigenetics mechanisms to development of cells and organisms and the biological basis of diseases. In addition the book focuses on immunology and the role of viruses in epigenetics. The last part of the book highlights proteins and peptides as epigenetic modulators.

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