This treatise had its origins in the authors' strong opinion that
the discovery of new drugs, especially of innovative therapeutic
agents, really does not happen as a spontaneous sequel to investiga
tive research, no matter how penetrating such research may be.
Rather, it seemed to us that the discovery of innovative
therapeutic agents was a very active process, existing in and of
itself, and demanding full attention-it was not simply a passive,
dependent by-process of investigative research. And yet, many
researchers some close confreres of the authors, others more
distant-believed otherwise. We felt that their view reflected
unrealistic thinking and that reality probably lay closer to what
Beyer" maintained: We are taught to believe that if we can
understand a disease it should be easy enough to figure out, say,
the molecular configuration of a definitive receptor mechanism
somewhere along the line and to design a specific drug . . . . And
so we start out to understand the disease but never get around to
doing much about therapy. The authors very soon realized that there
was essentially no quantitive information available on just where
and how innovative therapeutic agents were discovered. There were
only anecdotal accounts, and these were able to be selected and
presented in ways that could be used to defend any point of view."
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