Electricity and Magnetism (E&M) underlies many lifesaving medical devices, such as magnetic resonance imaging scanners, neural stimulators, and heart pacemakers. But E&M also attracts its share of bogus health claims, such as biomagnetic therapy. How do you separate the good from the bad? Sometimes it's not easy: experiments are prone to artifacts, theories are limited by assumptions, and clinical trials can result in ambiguities. In this book, the author separates the wheat from the chaff, showing which applications of E&M are bogus and which are not. This book takes the reader on a tour through a range of fascinating phenomena, from effects that are constant in time at one extreme, such as transcranial direct current stimulation of the brain, to the millimeter-wave whole-body scanners which are familiar to frequent flyers at the other. Along the way, the author looks in depth at the dispute about power line magnetic fields and leukemia, a case study in what can go wrong when dubious claims inflame unjustified fears. The debate about cell phones and brain cancer still rages today, particularly for the microwave frequencies encountered with new 5G technology. Recently, the so-called Havana Syndrome has been attributed to microwave weapons, but the underlying biophysics of such weapons is unclear. For all these encounters with electricity and magnetism, the author, an eminent biophysicist, uses science and evidence to sort out fact from fantasy. This book is aimed at general readers who want to make sense of the mysterious and often controversial ways in which E&M interacts with the human body. It is also ideal for students and professionals in bioscience and health-related fields who want to learn more without getting overwhelmed by theory.

This book addresses current topics on pathogenic Vibrio spp. from a comprehensive and holistic perspective. Here, experts in the field provide timely chapters, ranging from genomics, pathogen emergence, and epidemiology to pathogenesis, virulence regulation and host colonization. Questions addressed include: How does climate change affect the spread of these bacteria? What is the status of current vaccines? Are there novel therapeutic options to treat Vibrio infections? Is there likelihood of emergence of new pathogenic strains or species? Can insights from mathematical models and epidemiology lead to prediction of pathogen outbreaks? Recent decades have seen a steady increase in Vibrio spp. infections originating in aquatic and marine habitats, driven by higher human population densities, warming of polluted oceans, natural and human-made disasters, and mass seafood production. These conditions increase the likelihood of pathogenic Vibrio spp. coming into contact with humans, making their study even more timely and relevant as these problems escalate over time. This book is a valuable resource for health management professionals, experienced microbiologists/ microbial ecologists, and early career scientists alike who want to learn more about these important environmental human pathogens. The ideas and technologies presented in this book for preventing, controlling, and monitoring Vibrio spp. infections contribute to the UN Sustainable Development Goal 3: Good Health and Well-Being.

Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.

In 1948, when "Mrs. G.," hospitalized with debilitating rheumatoid arthritis, became the first person to receive a mysterious new compound--"cortisone"--her physicians were awestruck by her transformation from enervated to energized. After eighteen years of biochemical research, the most intensively hunted biological agent of all time had finally been isolated, identified, synthesized, and put to the test. And it worked. But the discovery of a long-sought "magic bullet" came at an unanticipated cost in the form of strange side effects. This fascinating history recounts the discovery of cortisone and pulls the curtain back on the peculiar cast of characters responsible for its advent, including two enigmatic scientists, Edward Kendall and Philip Hench, who went on to receive the Nobel Prize. The book also explores the key role the Mayo Clinic played in fostering cortisone's development, and looks at drugs that owe their heritage to the so-called "King of Steroids."

Atlas of Mycobacterium Tuberculosis reveals in-depth information about mycobacterium tuberculosis which has never before been reported. Using atomic force microscopy (AFM), the in-depth phenotypic interaction that occurs in different stages of the tuberculosis lifecycle is illustrated, including resting, exponential, and dormant states. Coverage also includes the macroscopic and microscopic anatomy of mycobacterium, including pigmentation, morphology of colonies, size and shape, and the phenotypic changes from susceptible to resistant, all shown with images from electronic and atomic force microscopes. This book will open a new window into the results of molecular changes at the cellular level, guiding researchers and scientists to think in new ways about the area of cell wall and the reproductive and drug resistance phenomena surrounding tuberculosis.

Genetics, Genomics and Fish Phenomics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions, with hhis volume focusing on genetics, genomics, and phenomics of fish.

In 1964, the release of Dr. Bernard Rimland's book, Infantile Autism, revolutionized the autism field by providing the autism community with much-needed guidance on how to understand and treat individuals on the spectrum. He single-handedly realigned the field from a psychodynamic, parent-blaming perspective to a scientific, physiological course of action. This 50th anniversary edition presents the original book with contributions from leaders in the autism field, including Drs. Martha Herbert and Simon Baron-Cohen, who celebrate Dr. Rimland's exceptional work, and place his findings within the context of autism as we understand it today. Bringing Dr. Rimland's findings up to date for a new generation of readers, this book will be fascinating reading for parents and those on the autism spectrum as well as professionals working with autism and anyone with an interest in autism and/or psychological theory.

Biostatistics for Practitioners: An Interpretative Guide for Medicine and Biology deals with several aspects of statistics that are indispensable for researchers and students across the biomedical sciences. The book features a step-by-step approach, focusing on standard statistical tests, as well as discussions of the most common errors. The book is based on the author's 40+ years of teaching statistics to medical fellows and biomedical researchers across a wide range of fields.

The perfect complement to Nursing Research: Generating and Assessing Evidence for Nursing Practice, 11th Edition, this knowledge-building Resource Manual strengthens students' understanding of concepts from the textbook and enhances their ability to confidently appraise and critique research studies. With an emphasis on careful reading and critical appraisal of actual studies, systematic learning exercises reinforce the acquisition of basic research skills fundamental to designing and planning one's own study. The Resource Manual appendices cover a range of nursing research endeavors, including critical appraisals of two research reports, two grant applications, and thirteen full research reports encompassing qualitative, qualitative, and mixed-methods studies, an instrument development study, and an evidence-based practice project report. The Resource Manual is accompanied by the invaluable online Toolkit, a must-have, timesaving innovation for students and seasoned researchers. Refined and easily adaptable research tools, available as editable Word files, address a broad range of research situations and can be customized to meet your specific needs. Crossword Puzzles provide an entertaining and challenging review of key terms and concepts. Study Questions encourage critical thinking and reinforce the most relevant content from each textbook chapter. Application Exercises hone students' ability to read, comprehend and critique nursing studies most effectively. Full research reports in the robust appendices cover a wide range of endeavors. TheToolkit delivers fast online access to dozens of timesaving, adaptable resources that can be downloaded and customized to meet your specific needs.

Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials.

Bioengineering is the application of engineering principles to address challenges in the fields of biology and medicine encompassing the principles of engineering design to the full spectrum of living systems. In surgery, recent advances in minimal invasive surgery and robotics are the culmination of the work that both engineers and surgeons have achieved in the medical field through an exciting and challenging interface. This interface rests on the medical curiosity and engineering solutions that lead eventually to collaboration and development of new ideas and technologies. Most recently, innovation by surgeons has become a fundamental contribution to medical research in the surgical field, and it is through effective communication between surgeons and biomedical engineers and promoting collaborative initiatives that translational research is possible. Bioengineering for Surgery explores this interface between surgeons and engineers and how it leads to innovation processes, providing clinical results, fundraising and prestige for the academic institution. This book is designed to teach students how engineers can fit in with their intended environment and what type of materials and design considerations must be taken into account in regards to medical ideas.

It is clear that many fascinating problems still remain to be addressed in parasite transmission modelling, from better understanding of transmission processes and natural history of infection to investigating the impact of ecological and spatial scales, climate change, host immunity and social behaviour, parasite-host evolutionary dynamics and parasite community ecology on parasite transmission. This book captures some of the advances made in recent years and provides indications of ways forward for addressing these questions by shedding light on developments in conceptual frameworks and modelling tools as well as the emergence of new data forms for aiding model construction, testing and analysis. Another important advance has been the parallel development of robust computationally-intensive statistical methods to allow model testing and parameterization by aiding the fitting of models to complex data. This is an exciting area of work, which we believe will broaden the scope of mathematical modelling in investigating parasite transmission processes. In particular, we expect this advance will now allow modellers to begin the successful development and analysis of mechanistically-rich models of parasite transmission that will facilitate better integration of the variety of mechanisms increasingly recognized as important in simultaneously affecting transmission, including abiotic processes, trophic and evolutionary interactions, movement in space, and behaviour and even physiology of the individual. We foresee a continuing bright future for using mathematical modelling to clarify parasite transmission dynamics and address problems related to effective parasite control. Ultimately, through this improved application of models to research and management, we expect that parasite control would be an achievable goal bringing benefits to a vast number of our fellow human beings.

The Temporal Lobe, Volume 187 covers the exponential growth of studies on the relationships between brain and language/cognition, many of which involved the temporal lobe. This volume summarizes research on the anatomy and function of the temporal lobe under both normal and pathological conditions. In addition, it discusses the interactions of the temporal lobe with other brain structures. The book highlights the role of the temporal lobe in language processing as well as vision, object, face recognition and processing. The book also discusses the temporal lobe's role in reading, speech and the processing of color, music, action and memory. Temporal lobe disorders, assessments and treatments are also covered, including encephalitis, Alzheimer's, epilepsy, Korsakov's syndrome, and more.

'A work of exhilarating scope and relevance ... What a rare and powerful experience to feel a book in your very body' Naomi Klein 'Health is not something we can attain as individuals, for ourselves, hermetically sealed off from the world around us. An injury to one is an injury to all.' Our bodies, societies and planet are inflamed. In this boldly original book, renowned political economist Raj Patel teams up with physician Rupa Marya to illuminate the hidden relationships between human health and the profound injustices of our political and economic systems. In doing so, they offer a radical new cure: the deep medicine of decolonization. Journeying through the human body - our digestive, endocrine, circulatory, respiratory, reproductive, immune, and nervous systems - Marya and Patel show how inflammation is connected not just to the food that we eat, the air that we breathe and access to healthcare, but is also linked to the traumatic events we experience and the very model of health that doctors practice: one which takes things apart, rather than seeking to bring ideas and lived experiences together. Combining the latest scholarship on globalization and biology with the stories of patients in marginalized communities and the wisdom of Indigenous groups, Inflamed points the way toward a medicine that heals what has been divided and has the potential to transform not only our bodies but the world.

This book demonstrates the beneficial effects in brain circuits involving memory and attention, reward and social values, decision making and coordination, creativity and persistence of the skills and expertise of continuing education and exposure to the Arts; including chess practice, music/counting, college education and watching movies. These activities were reviewed and investigated using full-spectrum, advanced quantitative imaging techniques. The book highlights extensive applications for this research in common diseases, together with cutting-edge and full-spectrum static and dynamic, functional and structural, regional and inter-network, imaging and phenotypic scales. It will capture the interest of researchers in the areas of neurodevelopmental, neuroplasticity and neuropsychiatric imaging and correlation, as well as disease diagnosis and treatment, and could help convey the methodological innovation and neuroscientific applications of important educational, health and arts/science-related topics.

Carnosine ( -alanyl histidine) is a water-soluble dipeptide. It is mainly distributed in the skeletal muscles and in the brain. It is widely recognized that carnosine has various functions including maintenance of the acid-base balance, antioxidant, protective chelating, and anti-glycation activity. In this book, Chapter One aims to discuss the properties of carnosine and its role in the prevention/inhibition of the oxidation processes occurring in meat and meat products, which are associated with the deterioration of their quality characteristics. Chapter Two reviews the perspective role of carnosine in tumor-related phenomena. Chapter Three reviews the possible mechanisms of neuroprotective functions of carnosine, and discusses the development of drugs for neurodegenerative diseases from food-derived carnosine. Chapter Four studies the neurotropic and protective effects of L-carnosine. Chapter Five focuses on the protective effects of carnosine and its derivative trolox-carnosine against inflammation and oxidative stress in experimental arthritis, carrageenan induced hind paw edema, chondrocytes under H2O2 injury and degradation of hyaluronan.

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient's genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Written by Yosef D. Dlugacz--an internationally recognized expert in the field of performance improvement and quality management--Measuring Health Care is a practical guide for the understanding and application of measurement methods in health care facilities.

This invaluable text shows students and professionals how measurements and data can be used to balance quality services and financial viability and how measures can help to evaluate and improve organizational, clinical, and financial processes. The book explains the various performance measurement methods used in health care and shows their practical impact on clinical patient outcomes.

The volume is grounded in the transition from a physician-centered, volume-based reimbursement system to a quality-driven, data-centered culture. The book explores the primary roles of performance assessment and outcomes measure in the current health care environment. Measuring Health Care combines extensive theoretical understanding with experience and offers examples from the author's pioneering quality management leadership.

This book guides medical researchers through all stages of transforming their scientific data and ideas into a published paper. Many researchers in medicine, including the life sciences and health sciences, struggle to get their research written and published. Manuscripts are typically rejected and/or sent back for revisions several times before ever being published. One reason for this is that researchers have not received much instruction in the specific subjects and skills needed to write and publish scientific medical papers: research methodology, ethics, statistics, data visualization, writing, revising, and the practicalities of publishing. Instead of wasting the reader's time discussing trivialities of punctuation, spelling, etc., this book tackles all the major scientific issues that routinely lead to manuscripts getting rejected from the journals. The section "Preparing" covers the range of methodological, ethical, and practical aspects that researchers need to address before starting to write their paper. The section "Analyzing" reviews commonplace problems in the statistical analysis and presentation, and how to resolve those problems. The section "Drafting" describes what to write in all the various parts of a paper (the Introduction, Methods, Results, Discussion, Abstract, etc.) The section "Revising" explains and illustrates how to improve the writing style of any manuscript. The section "Publishing" discusses how to navigate the peer review process and all other practical aspects of the publishing phase. This book draws on the author's decade of experience as an independent medical writer and research consultant, but it is not written merely as the personal opinion of yet another expert. The entire book is grounded in the existing scientific and scholarly literature, with extensive references and a lengthy annotated bibliography, so readers can quickly obtain more information on any aspect they want. Thus this book provides a more evidence-based, scholarly account of how medical scientific papers should be written, in order to improve medical communication and accelerate scientific progress. After reading this entire book cover to cover, medical researchers will know how to write better quality medical papers, and they will be able to publish their work in better journals with less time and struggle. This book is essential reading for anyone conducting research in clinical medicine, life sciences, or health sciences.

Sentiment analysis research has been started long back and recently it is one of the demanding research topics. Research activities on Sentiment Analysis in natural language texts and other media are gaining ground with full swing. But, till date, no concise set of factors has been yet defined that really affects how writers' sentiment i.e., broadly human sentiment is expressed, perceived, recognized, processed, and interpreted in natural languages. The existing reported solutions or the available systems are still far from perfect or fail to meet the satisfaction level of the end users. The reasons may be that there are dozens of conceptual rules that govern sentiment and even there are possibly unlimited clues that can convey these concepts from realization to practical implementation. Therefore, the main aim of this book is to provide a feasible research platform to our ambitious researchers towards developing the practical solutions that will be indeed beneficial for our society, business and future researches as well.

Dr. Catalano has for the last ten years been doing consulting for the Pharmaceutical Industry. During his consulting he discovered that small businesses such as, generic, startups, and virtual companies do not have the budget or the resources to apply the computer software utilized in project management and therefore do not apply project management principles in their business model. This reduces their effectiveness and increases their operating cost. Application of Project Management Principles to the Management of Pharmaceutical R&D Projects is presented as a paper-based system for completing all the critical activities needed apply the project management system. This will allow these small business to take advantage of the project management principles and gain all the advantages of the system. This book will be beneficial for beginners to understand the concepts of project management and for small pharmaceutical companies to apply the principles of project management to their business model.

The world we live in is hugely unequal. People in a better socioeconomic position do not only lead more comfortable lives, but also longer and healthier lives. This is true not only in the poorer parts of the world but also in the richest countries, including the advanced welfare states of Western Europe which have successfully pushed back poverty and other forms of material disadvantage. Why are health inequalities - systematically higher rates of disease, disability, and premature death among people with a lower level of education, occupation or income - so persistent? How can we expect to reduce this when it persists even in the most advanced states? Written by a leading figure in public health, this book looks to answer these questions by taking a broad, critical look at the scientific evidence surrounding the explanation of health inequalities, including recent findings from the fields of epidemiology, sociology, psychology, economics, and genetics. It concludes that a simplistic view, in which health inequalities are a direct consequence of social inequality, does not tell us the full story. Drawing upon a unique series of studies covering 30 European countries and more than three decades of observations, it shows that health inequalities are partly driven by autonomous forces that are difficult to counteract, such as educational expansion, increased social mobility, and rapid but differential health improvements. Finally, the book explores how we might use these new findings to continue our efforts to build a healthier and more equal future. Offering a truly multidisciplinary perspective and an accessible writing style, Health Inequalities is an indispensable resource for health researchers, professionals, and policy-makers, as well as for social scientists interested in inequality.

Research on nutrition has grown into one of the most challenging and innovative health-related scientific disciplines during the past decade. New advances in basic and applied nutritional research help to emphasize several health challenges of the global population. In this book, authors present current research in the study of nutrition and human health. Topics discussed here include the correlation between obesity and iron deficiency anemia; the role of exercise, inflammation and chronic disease in zinc transport; protein supplementation in an athletic environment; efficacy and safety of dietary guanidinoacetic acid and methyl donor loading; the utilization of new creatine formulations in human nutrition; the evaluation of medicinal plant antioxidants and anti-inflammatory activities; the role of edible wild plants in human nutrition; factors influencing fruit and vegetable consumption in adolescents; and novel perspectives in physical inactivity-related mechanisms of sarcopenia.