In recent years, serine proteases and matrix metalloproteinases
(MMPs) have gained considerable attention in tumor biology. For
most of these proteases, their expression is a reliable indication
of ongoing tissue remodeling. This book provides a comprehensive
evaluation of the mechanisms of action of proteases and their
inhibitors in tumor biology. The first part provides the reader
with a selective overview of the molecular biology of serine
proteases, MMPs and their physiological inhibitors. The most
important proteases and their physiological as well as synthetic
inhibitors are evaluated in the most relevant models of
experimental and human cancer. The clinical aspects are also taken
into account.
This volume offers an update on this challenging aspect of cancer
treatment, its interest bias, and possible clinical implication.
General
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