This book covers the latest developments in rolling circle
amplification (RCA) technology with applications in clinical
diagnostic tests and molecular medicine. Topics covered include new
enzymes useful in RCA, techniques involving RCA for enhanced signal
amplification, novel RCA diagnostics, sensors for expediting RCA
detection, and prospective RCA-based therapeutics. This is a
valuable book for university professors and students in the field
of biomedical engineering and biomolecular pharmacology as well as
R&D managers of biotechnology and biopharmaceutical companies.
Specifically, this book: Reviews prospective RCA-based
therapeutics, including RCA-derived DNA nanoparticles that strongly
bind to cancer cells Expands readers' understanding of sensor
systems for expediting detection of RCA products by using
probe-tagged magnetic nanobeads Maximizes reader insights into
novel RCA diagnostics, such as PNA openers-assisted RCA for
detection of single target cells and in situ RCA diagnosis of
cancer cells and malignant tissues Presents innovative methods for
quasi-exponential enhancement of RCA-generated signals, such as
nicking enzyme-assisted cascade RCA and RCA coupled with
loop-mediated amplification Advance Praise for Rolling Circle
Amplification (RCA): "This book provides a badly needed compendium
of innovative RCA methods and applications. It should help further
increase the community of scientists that have employed RCA in
research and diagnostic programs."- Charles Cantor, Professor
Emeritus of Biomedical Engineering, Boston University Executive
Director, Retrotope Inc. (USA) "In this new book Vadim Demidov has
assembled an enticing menu of articles that illustrate the
evolution of the RCA field, including improved protein parts for
building superior DNA nanomachines, enhanced modalities of
amplification and detection, diagnostic applications, and even a
sampling of potential therapeutic applications. The reader will
appreciate that while RCA has come of age, there is no lack of
exciting surprises, turns, and twists in the continuing evolution
of the technology."- Paul Lizardi, Professor of Pathology, Yale
University School of Medicine (retired) Investigator, University of
Granada, Spain, President, PetaOmics, Inc., San Marcos, Texas.
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