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Prion Phenomena in Neurodegenerative Diseases - New Frontiers in Neuroscience (Hardcover)
Loot Price: R6,147
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Prion Phenomena in Neurodegenerative Diseases - New Frontiers in Neuroscience (Hardcover)
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The most fascinating and unique feature of prion diseases is that
they are caused almost exclusively by a proteinaceous and
infectious particle termed prions by the Nobel Prize laureate S B
Prusiner, who discovered this class of pathogens. In the latter
part of the 1990s, mad-cow disease, a disease caused by prions
acquired through foodborne transmission, raised unprecedented
public concern due to the concrete possibility that prions in
animals could be transmitted to humans through the food chain. For
roughly two decades, prions were under intense scrutiny and many
studies were undertaken worldwide. These investigations have led
our community to a better risk assessment and management of prion
diseases in humans and in animals, substantially limiting the
possibility of new prion epidemics. Nowadays, prions have been
brought once again to the foreground after the discovery that a
variety of neurodegenerative diseases, in particular Alzheimer's
disease, Parkinson's disease and amyotrophic lateral sclerosis,
share fundamental features with prions, including protein
misfolding and aggregation in the brain, cell-to-cell transmission
and in vivo infectivity. Therefore, studying prions might help to
understand the pathological mechanism of these disorders. The Prion
Phenomena In Neurodegenerative Diseases: New Frontiers in
Neuroscience is a book that benefits from the contribution of
leading scientists in different fields of neuroscience, including
Gianluigi Zanusso, Holger Wille, Fabrizio Tagliavini, Andrew F
Hill, Jerson L Silva, Vladimir N Uversky, Henrike Heise, David W
Colby, Neil R Cashman and the Nobel Prize laureate Eric R Kandel.
This chapter collection discusses the development of prions and
their various diseases, and provides a detailed overview about the
state of the art of the novel prion phenomena observed in other
fatally damaging protein misfolding disorders. This book represents
an up-to-date review of different protein-misfolding diseases,
serving as an invaluable tool for both specialized researchers
working in the field of neurodegeneration and for a broad spectrum
of academic readers that wish to learn more about the prion
phenomena.
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