Anaphylaxis is an immediate-type allergic reaction involving the
whole organism. It is the most life-threatening allergic condition.
Although there are few exact epidemiological data regarding
prevalence, estimates regarding insect sting anaphylaxis range from
1-3 0n the general population, but much higher values have been
reported by some authors for food and drug-induced anaphylaxis.
Anaphylaxis is the main acute killer of allergic individuals.
Although anaphylaxis was discovered at the beginning of the 20th
century, there are still many unresolved issues. These include
non-IgE-mediated anaphylactoid reactions, non-immunologically
mediated anaphylactoid (pseudo-allergic) reactions,
pathophysiological events at the microcirculatory level,
appropriate therapy for the acute reaction, strategies for
prevention, public education about the problem and new approaches
to prevention and therapy at the IgE level. All these subjects are
discussed in this book.
Since anaphylaxis occurs acutely and is unforeseen, it is very
difficult to organize controlled studies regarding therapy and
prevention. The spectrum of symptomatology covers many clinical
areas (skin, respiratory, cardiovascular and gastrointestinal
system), therefore inter-disciplinary approaches are necessary for
progress in the field. There is widespread uncertainty among
physicians about therapy, especially concerning self-administered
treatment.
In this important book, an multidisciplinary group of experts
explore the pathophysiology of different types of anaphylactic and
anaphylactoid reactions. Evidence is presented on the epidemiology
of these conditions while problems relating to diagnosis, therapy
and prevention areexamined in detail. This thorough and up-to-date
coverage of the subject will be of great interest to all clinical
immunologists, researchers and physicians who deal with this
life-threatening condition.
"Related Novartis Foundation symposia: " 252 Generation and
effector functions of regulatory lymphocytes
Chair: Jean-Francois Bach
Immunoinformatics: bioinformatic strategies for better
understanding of immune function
Chair: Hans-Georg Rammensee
Cancer and inflammation
Chair: Siamon Gordon
General
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