This book is the proceedings of the Falk Symposium No. 138 on
"State of the Art of Hepatology: Molecular and Cell Biology" (part
of the XII International Falk Liver Week 2003 in honour of Hans
Poppera (TM)s 100th birthday, held on October 20--11, 2003), and
reflects the tremendous advances in the science of hepatology both
at the molecular as well as the cellular level.
The book comprises four major sections. In Section I, the basic
aspects of liver cell biology are covered, including RNA
metabolism, regeneration, transport and metabolic functions, as
well as fibrogenesis and malignant transformation. In Section II,
the novel field of stem cell plasticity and cell therapy for liver
diseases is discussed in detail, including stem cell biology,
hepatocyte transdifferentiation from extrahepatic stem cells and
their therapeutic use for liver cell repopulation, as well as
hepatocyte transplantation. In Section III, novel therapeutic
strategies for liver cirrhosis and hepatocellular carcinoma are
presented, including the reversal of liver fibrosis, oncolytic
biotherapy and different concepts of gene therapy for
hepatocellular carcinoma. In Section IV, novel aspects of gene
therapy and prevention of liver diseases are addressed, including
small interfering RNAs, ribozymes, antisense oligonucleotides, as
well as DNA vaccination.
An international faculty of outstanding scientists from
different research areas presents the state of the art on these
most important aspects of hepatology and their perspectives for
future developments. Molecular and cell biology are at the very
centre of research developments in modern hepatology and are of
interest and importance to both basic scientists aswell as
clinicians involved in patient care.
General
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