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Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > Cytology

The Tumor Microenvironment - Methods and Protocols (Hardcover, 1st ed. 2016): Josie Ursini-Siegel, Nicole Beauchemin The Tumor Microenvironment - Methods and Protocols (Hardcover, 1st ed. 2016)
Josie Ursini-Siegel, Nicole Beauchemin
R3,770 R3,429 Discovery Miles 34 290 Save R341 (9%) Ships in 10 - 15 working days

This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various "omics"-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.

T-Helper Cells - Methods and Protocols (Hardcover, 2014 ed.): Ari Waisman, Burkhard Becher T-Helper Cells - Methods and Protocols (Hardcover, 2014 ed.)
Ari Waisman, Burkhard Becher
R4,176 R3,306 Discovery Miles 33 060 Save R870 (21%) Ships in 10 - 15 working days

T-Helper Cells: Methods and Protocols presents a broad selection of cutting edge protocols that will enable the reader to capture the unique features of TH cells with tools developed for the isolation of TH cells from various tissues and subsequent analysis of their functional properties in vitro, ex vivo and in vivo. Chapters cover methods of isolating T cells from various tissues in mice, protocols for the analysis of T cell function and phenotype using various cutting edge technologies, methods allowing for the manipulation of T cell function in vitro and in vivo, and in vivo models of diseases in which T cells play a central role in the pathogenesis. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, T-Helper Cells: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further the study of this amazingly versatile and potent cell type.

Cell Biology Playing Cards - Cell Biology Playing Cards: Art Card Deck (Single Pack) (Cards): Thomas D. Pollard, William C.... Cell Biology Playing Cards - Cell Biology Playing Cards: Art Card Deck (Single Pack) (Cards)
Thomas D. Pollard, William C. Earnshaw, Graham Johnson, Jennifer Lippincott-Schwartz
R241 Discovery Miles 2 410 Ships in 10 - 15 working days

Fun and educational, these unique playing cards are beautifully illustrated with detailed cells and cellular structures - perfect for science lovers and cell biologists of all ages! Card faces features favorite illustrations from the textbook Cell Biology by Thomas D. Pollard et al. - from the clathrin triskelion and its three-fold symmetry on the 3 to mitotic chromosome structure on the Queen! Standard 52-card deck with illustrations of endosomes and lysosome, mother and daughter centrioles, membrane traffic, eukaryotic phylogenetic tree, three cytoskeletal polymers, and more. Jokers feature illustrations of autophagy (red joker) and ribosome, V-type ATPase, CRISPR/Cas, bacterium (black joker). Fourteen different card faces in all featuring the well-loved cellular illustrations of Graham Johnson.

Human Cell Transformation - Advances in Cell Models for the Study of Cancer and Aging (Hardcover, 1st ed. 2019): Johng S. Rhim,... Human Cell Transformation - Advances in Cell Models for the Study of Cancer and Aging (Hardcover, 1st ed. 2019)
Johng S. Rhim, Anatoly Dritschilo, Richard Kremer
R3,755 R3,349 Discovery Miles 33 490 Save R406 (11%) Ships in 10 - 15 working days

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Fine Needle Aspiration Cytology - 100 Interesting Cases (Hardcover, 1st ed. 2020): Pranab Dey Fine Needle Aspiration Cytology - 100 Interesting Cases (Hardcover, 1st ed. 2020)
Pranab Dey
R6,101 Discovery Miles 61 010 Ships in 7 - 11 working days

This book discusses a broad selection of interesting cases of fine needle aspiration cytology (FNAC), which offer valuable insights into the diagnosis of cytology cases in routine practice. It provides the salient clinical history along with representative microphotographs of the routine smears. The content is divided into 100 chapters, with each chapter covering an individual case in detail. The book also addresses immunocytochemistry and other ancillary techniques that can help to diagnose lesions. Richly illustrated with more than 900 images, the book offers a valuable guide to diagnosis and self-evaluation for students/trainees/examinees of pathology and cytology practitioners alike.

Respirology (Hardcover, 1st ed. 2016): Mieczyslaw Pokorski Respirology (Hardcover, 1st ed. 2016)
Mieczyslaw Pokorski
R3,741 R2,871 Discovery Miles 28 710 Save R870 (23%) Ships in 10 - 15 working days

The book addresses functional changes associated with or resulting from pulmonary diseases. Population-based clinical, epidemiological, and multicenter investigations are presented to provide a comprehensive update on prevalent respiratory problems; the exemplars are respiratory tract infections, tobacco abuse, chronic obstructive lung diseases, or socio-economic influence on morbidity. Novel issues related to the function of the carotid body, an organ generating hypoxic hyperventilation also are tackled. Significant insights into a wide range of related conditions are provided. Chapters are relevant to the broad readership as they examine health care quality, effectiveness of therapeutic strategies, the patient quality of life, and other relevant health issues. The authors present late-breaking knowledge and aim at thought-stimulating viewpoints on timely clinical topics in respiratory medicine.

Medical Applications of iPS Cells - Innovation in Medical Sciences (Hardcover, 1st ed. 2019): Haruhisa Inoue, Yukio Nakamura Medical Applications of iPS Cells - Innovation in Medical Sciences (Hardcover, 1st ed. 2019)
Haruhisa Inoue, Yukio Nakamura
R3,477 R2,639 Discovery Miles 26 390 Save R838 (24%) Ships in 10 - 15 working days

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

PI3K-mTOR in Cancer and Cancer Therapy (Hardcover, 1st ed. 2016): Nandini Dey, Pradip De, Brian Leyland-jones PI3K-mTOR in Cancer and Cancer Therapy (Hardcover, 1st ed. 2016)
Nandini Dey, Pradip De, Brian Leyland-jones
R4,399 R3,961 Discovery Miles 39 610 Save R438 (10%) Ships in 10 - 15 working days

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

Tandem Repeat Polymorphisms - Genetic Plasticity, Neural Diversity and Disease (Hardcover, 2013 ed.): Anthony J. Hannan Tandem Repeat Polymorphisms - Genetic Plasticity, Neural Diversity and Disease (Hardcover, 2013 ed.)
Anthony J. Hannan
R3,735 R3,329 Discovery Miles 33 290 Save R406 (11%) Ships in 10 - 15 working days

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

Nucleic Acids as Molecular Diagnostics (Hardcover): Andreas Keller, Eckart Meese Nucleic Acids as Molecular Diagnostics (Hardcover)
Andreas Keller, Eckart Meese
R2,614 R2,322 Discovery Miles 23 220 Save R292 (11%) Ships in 10 - 15 working days

By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.

Human Molecular Biology Laboratory Manual (Paperback): Stefan Surzycki Human Molecular Biology Laboratory Manual (Paperback)
Stefan Surzycki
R2,055 R1,853 Discovery Miles 18 530 Save R202 (10%) Ships in 10 - 15 working days

"Human Molecular Biology Laboratory Manual" offers a hands-on, state-of-the-art introduction to modern molecular biology techniques as applied to human genome analysis. In eight unique experiments, simple step-by-step instructions guide students through the basic principles of molecular biology and the latest laboratory techniques. This laboratory manual's distinctive focus on human molecular biology provides students with the opportunity to analyze and study their own genes while gaining real laboratory experience.
A Background section highlighting the theoretical principles for each experiment.
Safety Precautions.
Technical Tips.
Expected Results.
Simple icons indicating tube orientation in centrifuge.
Experiment Flow Charts
Spiral bound for easy lab use

Non-Viral Gene Delivery Vectors - Methods and Protocols (Hardcover, 1st ed. 2016): Gabriele Candiani Non-Viral Gene Delivery Vectors - Methods and Protocols (Hardcover, 1st ed. 2016)
Gabriele Candiani
R3,686 R3,345 Discovery Miles 33 450 Save R341 (9%) Ships in 10 - 15 working days

This volume provides readers with a wide collection of the latest and readily reproducible technical protocols available in the field of non-viral gene delivery vectors. The chapters in this book are organized into three major parts: Part I is a section on conventional bolus gene delivery vectors that introduces typical transfection approaches relying on the addition of transfectants to the cell culture medium where the cells are grown in; Part II covers stimuli-responsive bolus transfectants and topics on gene delivery complexes made of smart polymers or stimuli-responsive polymers that change according to the environment they are in and delivered by dripping into cells; Part III discusses examples of substrate-mediated gene delivery-also termed reverse transfection-and the immobilization of a gene delivery vector onto a surface as opposed to more typical bolus delivery from the medium. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Non-Viral Gene Delivery Vectors: Methods and Protocols is written for experimentalists, and is an essential part of many laboratory bookshelves. This book will help novice and professionals alike succeed in their research in this field.

Epidermal Cells - Methods and Protocols (Hardcover, 3rd ed. 2014): Kursad Turksen Epidermal Cells - Methods and Protocols (Hardcover, 3rd ed. 2014)
Kursad Turksen
R4,799 R3,864 Discovery Miles 38 640 Save R935 (19%) Ships in 10 - 15 working days

Reflecting over three decades of advances, "Epidermal Cells: Methods and Protocols, Third Edition" underscores these advances in our understanding of epidermal biology with updated and entirely new protocols that compliment and extend the earlier edition. The inclusion of protocols useful for both in vitro and in vivo studies reflects many useful developments in the field. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Dependable and easy to follow, "Epidermal Cells: Methods and Protocols, Third Edition" serves researchers working to accelerate the work in this vital field of study.

Gene and Cell Delivery for Intervertebral Disc Degeneration (Hardcover): Raquel Madeira Goncalves, Mario Adolfo Barbosa Gene and Cell Delivery for Intervertebral Disc Degeneration (Hardcover)
Raquel Madeira Goncalves, Mario Adolfo Barbosa
R2,969 Discovery Miles 29 690 Ships in 10 - 15 working days

Intervertebral disc degeneration is one of the major causes of lower back pain for which the common therapeutic interventions are not efficient. A search for alternative therapies for lower back pain and intervertebral disc degeneration includes cell-based therapies. Unfortunately, intervertebral disc degeneration is avascular and thus a hostile environment for cell survival. Furthermore, cellular characterization in intervertebral disc degeneration, and particularly in the nucleus pulposus, is controversial, mainly due to lack of specific markers and species variability. This book adds to the knowledge on cellular and molecular therapies for intervertebral disc degeneration and associated lower back pain. Key Selling Features: Describes the ontogeny and phenotype of intervertebral disc cells Reviews the role that inflammation plays in disco-genic pain Highlights the types of cells that might be used as sources for treating degenerating intervertebral discs Summarizes current alternative therapies Explores methods for cell delivery into degenerated intervertebral discs

The X in Sex - How the X Chromosome Controls Our Lives (Paperback, New Ed): David Bainbridge The X in Sex - How the X Chromosome Controls Our Lives (Paperback, New Ed)
David Bainbridge
R559 R470 Discovery Miles 4 700 Save R89 (16%) Ships in 7 - 11 working days

A tiny scrap of genetic information determines our sex; it also consigns many of us to a life of disease, directs or disrupts the everyday working of our bodies, and forces women to live as genetic chimeras. The culprit--so necessary and yet the source of such upheaval--is the X chromosome, and this is its story. An enlightening and entertaining tour of the cultural and natural history of this intriguing member of the genome, "The X in Sex" traces the journey toward our current understanding of the nature of X. From its chance discovery in the nineteenth century to the promise and implications of ongoing research, David Bainbridge shows how the X evolved and where it and its counterpart Y are going, how it helps assign developing human babies their sex--and maybe even their sexuality--and how it affects our lives in infinitely complex and subtle ways. X offers cures for disease, challenges our cultural, ethical, and scientific assumptions about maleness and femaleness, and has even reshaped our views of human evolution and human nature.

Netter's Essential Biochemistry (Paperback): Peter Ronner Netter's Essential Biochemistry (Paperback)
Peter Ronner
R1,155 R1,085 Discovery Miles 10 850 Save R70 (6%) Ships in 10 - 15 working days

Concise writing, a focus on clinical applications, and superb illustrations make Netter's Essential Biochemistry, by Peter Ronner, PhD, the perfect choice for a basic understanding of biochemistry.. A single expert voice, informed by the insights of a team of reviewers, provides continuity throughout the text, presenting essentials of biochemical principles step by step. Summary diagrams help you grasp key concepts quickly, and end-of-chapter questions reinforce key concepts. Provides a highly visual, reader-friendly approach to the challenging area of biochemistry. Integrates the clinical perspective throughout the text, giving context and meaning to biochemistry. Frames every chapter with helpful synopses and summaries, and ends each chapter with review questions that reinforce major themes. Illustrates key concepts with beautifully clear drawings and diagrams of biochemical processes which are supplemented with art from the renowned Netter collection, bridging basic sciences with clinical practice. Student ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book as well as new materials (outlined above) designed to produce a more rounded learning experience.

The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology - Definitions, Criteria and... The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology - Definitions, Criteria and Explanatory Notes (Paperback)
Martha Bishop Pitman, Lester James Layfield
R1,737 R1,521 Discovery Miles 15 210 Save R216 (12%) Ships in 10 - 15 working days

This text and the terminology developed by the Papanicolaou Society of Cytopathology (P.S.C.) represents an important advance in the field of pancreaticobiliary cytopathology. This textbook/atlas is designed to present a comprehensive and state of the art approach to the cytologic diagnosis and reporting of pancreaticobiliary lesions. Chapters address each of the diagnostic categories defined by the P.S.C. The definition of each category along with the clinical pathologic entities contained within the category are discussed along with specific cytologic criteria for inclusion of a cytologic specimen within the category. Each chapter is lavishly illustrated demonstrating diagnostic criteria and examples of lesions contained within the category. Additionally, appropriate ancillary testing is discussed and where appropriate illustrated. Each chapter concludes with a discussion of appropriate management as well as estimates of malignancy risk for the category. The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology: Definitions, Criteria, Ancillary Testing and Management will provide the reader with a unified approach to diagnosing and reporting interpretations of cytologic specimens obtained from the pancreaticobiliary tract. This text/atlas will serve as a reference guide for pathologists, surgeons, endoscopists and radiologists.

Human Stem Cell Toxicology (Hardcover): James L. Sherley Human Stem Cell Toxicology (Hardcover)
James L. Sherley; Edited by (editors-in-chief) Diana Anderson; Contributions by Dipak Datta, Wenbin Deng, William G. Thilly, …
R4,926 Discovery Miles 49 260 Ships in 10 - 15 working days

This book addresses a long-standing problem in environmental toxicology and drug development, which new research advances are beginning to address. It will advance the scientific knowledge of toxicologists in a several different application areas, including environmental health sciences, pharmaceutical drug development, and medicine. It is relevant for Academics, Postgraduates, Undergraduates and Industrialists working in the areas of Toxicology, Pharmaceutical Sciences, Tissue Cell Biology and Stem Cell Biology. Competing books include the 2014 Handbook of Nanotoxicology, Nanomedicine, and Stem Cell Use in Toxicology. Cross-promote with Stem Cells: Regenerative Pharmacology, Drug Discovery & Development, edited by Timothy Allsopp and Chris Mason and planned for publication in the Drug Discovery Series in 2016.

Caveolins and Caveolae - Roles in Signaling and Disease Mechanisms (Hardcover, 2012): Jean Francois Jasmin, Philippe Frank,... Caveolins and Caveolae - Roles in Signaling and Disease Mechanisms (Hardcover, 2012)
Jean Francois Jasmin, Philippe Frank, Michael P Lisanti
R5,331 R4,267 Discovery Miles 42 670 Save R1,064 (20%) Ships in 10 - 15 working days

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

Cell Structure & Function (Paperback): Guy Orchard, Brian Nation Cell Structure & Function (Paperback)
Guy Orchard, Brian Nation
R1,151 Discovery Miles 11 510 Ships in 10 - 15 working days

Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series is written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science. Alongside volumes exploring specific biomedical themes and related laboratory diagnosis, an overarching Biomedical Science Practice volume gives a grounding in the professional and experimental skills with which any Biomedical Scientist must be equipped. The series: * Understands the complex roles of Biomedical Scientists in the modern practice of medicine * Understands the development needs of employers and the Profession * Addresses the need for understanding of a range of fundamental sciences in the context of Biomedicine * Places the theoretical aspects of Biomedical Science in their practical context The series is developed in partnership with and endorsed by the Institute of Biomedical Science. Visit www.ibms.org for more information. Cell Structure and Function describes the structural and functional features of the various types of cell from which the human body is formed. Focusing on normal cellular structure and function, it gives students and trainees a firm grounding in the appearance and behaviour of healthy cells and tissues on which can be built a robust understanding of cellular pathology. With cell structure and function correlated with clinical contexts throughout, Cell Structure and Function is the ideal introduction to cellular biology for any student of biomedical science. Online Resource Centre The Online Resource Centre to accompany the Fundamentals of Biomedical Science series features: For registered adopters of the book: * Figures from each book, available to download For students: * An interactive Virtual Microscope, encouraging the exploration of tissue samples * Video podcasts including interviews with practicing biomedical scientists, and 'in the lab' footage showing biomedical science in practice

Next Generation Sequencing in Cancer Research - Volume 1: Decoding the Cancer Genome (Hardcover, 2013 ed.): Wei Wu, Hani... Next Generation Sequencing in Cancer Research - Volume 1: Decoding the Cancer Genome (Hardcover, 2013 ed.)
Wei Wu, Hani Choudhry
R5,323 R4,411 Discovery Miles 44 110 Save R912 (17%) Ships in 10 - 15 working days

This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

Encyclopedia of Cell Biology (Hardcover, Annotated edition): Ralph A. Bradshaw, Philip D. Stahl Encyclopedia of Cell Biology (Hardcover, Annotated edition)
Ralph A. Bradshaw, Philip D. Stahl
R34,914 Discovery Miles 349 140 Ships in 10 - 15 working days

The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences.

Breast Cytopathology - Assessing the Value of FNAC in the Diagnosis of Breast Lesions. (Hardcover): M. Pinamonti, F. Zanconati Breast Cytopathology - Assessing the Value of FNAC in the Diagnosis of Breast Lesions. (Hardcover)
M. Pinamonti, F. Zanconati; Series edited by Philippe Vielh
R3,022 R2,609 Discovery Miles 26 090 Save R413 (14%) Ships in 10 - 15 working days

Breast cytopathology is a field characterized by practicality and diagnostic efficacy. This book focuses mainly on morphology, with helpful hints for recognizing benign lesions and the main features of malignancy. It reviews specific features of various lesions and the consequences of the diagnosis for the management of the patient. Each chapter contains high-quality cytology images accompanying the descriptions, including comparison images to distinguish the most important morphological features and to help in the differential diagnosis. Fine needle aspiration cytology (FNAC) sampling and preparation technique, fixation, staining, and principles of its interpretation are covered. Immunocytochemistry and ancillary techniques are outlined, as well as the main clinical and radiological features of breast lesions, and the cytological diagnostics of axillary lymph nodes. This publication will be of great use to medical practitioners in their first approach to breast cytopathology, as well as to pathologists and cytotechnicians with little to moderate experience in the field.

Analytical Techniques In DNA Sequencing (Hardcover): Brian K. Nunnally Analytical Techniques In DNA Sequencing (Hardcover)
Brian K. Nunnally
R5,839 Discovery Miles 58 390 Ships in 10 - 15 working days

While one marvels at the DNA generated by the Human Genome Project, perhaps just as significant and fascinating is the development of the amazing analytical technology that has permitted us entry into the genomic era and a whole new level of scientific understanding.

Analytical Techniques in DNA Sequencing takes a look at the various DNA sequencing techniques that were developed and put to use during and after the Human Genome Project. Nunnally makes a special effort to trace the development of this branch of research since the early days of radioisotope sequencing. Special attention is paid to the breakthrough Sanger Method (1977), as well as to several other techniques that improved the accuracy, improved the detection limits, and in a variety of ways dramatically reduced the time needed to generate a DNA sequence.

This comprehensive volume describes the improvements in DNA separation based on advanced capillary electrophoresis and microchip sequencing. It also looks at the use ofmass spectrometry and single molecule detection, and takes an in-depth look at the use of various fluorescence methods for the detection of sequencing fragments. One chapter is dedicated to chip-based microfabricated sequencing systems, which could well be the future of DNA sequencing.

The book's ten chapters, authored by a variety of leading experts in the field, include many of the far-reaching applications of DNA sequencing. Entire chapters are dedicated to DNA typing for forensics, a reevaluation of ancient DNA, and genome analysis.

Manipulation of Stem Cells for Disease Benefits (Hardcover): Travis S. Mason Manipulation of Stem Cells for Disease Benefits (Hardcover)
Travis S. Mason
R5,877 R4,270 Discovery Miles 42 700 Save R1,607 (27%) Ships in 10 - 15 working days

This collection of articles deals with the benefits of different types of stem cells sources, use, manipulation, and aspects for the treatment of chronic diseases. Topics include the role of calcium channel pathway/s in the regulation of neural stem cell differentiation; the evolutionary roles of the totipotent, pluripotent, or even multipotent stem cells; the derivations of multipotent MSCs; and potential canine-derived stem cell therapies for dogs. The scope of the book also provokes further studies into other topics, such as MSC differentiation into hepatocytes and the involvement of these cells with microRNA-133 in type 1 diabetes; the role of Vitronectin in the differentiation into endoderm; the extent to which the stemness of dental pulp stem cells might be useful; PBMCs as a source for pluripotent stem cells; yoga in possible synergy with the finding that bone marrow stromal cells provide relief from a laboratory reagent used as drug-mediated pain in spinal cord injury.

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