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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 4 Mitophagy (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 4 Mitophagy (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity,
Infection and Aging, Volume 4 - Mitophagy presents detailed
information on the role of mitophagy, the selective autophagy of
mitochondria, in health and disease, by delivering an in-depth
treatment of the molecular mechanisms involved in mitophagy
initiation and execution, as well as the role of mitophagy in
Parkinson's Disease, cardiac aging, and skeletal muscle atrophy.
The most current understanding of the proteins and pathways
involved in mitophagy are covered, with specific attention to Nix
and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy
in cancer, neurodegeneration, aging, infection, and inflammation is
also discussed providing essential insights into the pathogenesis
of a variety of mitochondria dysfunction-related diseases. This
book is an asset to newcomers as a concise overview of the current
knowledge on mitophagy, while serving as an excellent update
reference for more experienced scientists working on other aspects
of autophagy. From these well-developed foundations, researchers,
translational scientists, and practitioners may work to better
implement more effective therapies against some of the most
devastating human diseases. Volumes in the Series Volume 1:
Molecular Mechanisms. Elucidates autophagy's association with
numerous biological processes, including cellular development and
differentiation, cancer, immunity, infectious diseases,
inflammation, maintenance of homeostasis, response to cellular
stress, and degenerative diseases such as Alzheimer's, Parkinson's,
Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects
of the complex process of autophagy in a myriad of devastating
human diseases, expanding from a discussion of essential autophagic
functions into the role of autophagy in proteins, pathogens,
immunity, and general diseases. Volume 3: Role in Specific
Diseases. Explores the role of autophagy in specific diseases and
developments, including: Crohn's Disease, Gaucher Disease,
Huntington's Disease, HCV infection, osteoarthritis, and liver
injury, with a full section devoted to in-depth exploration of
autophagy in tumor development and cancer, as well as the
relationship between autophagy and apoptosis. Volume 4: Mitophagy.
Presents detailed information on the role of mitophagy, the
selective autophagy of mitochondria, in health and disease, by
delivering an in-depth treatment of the molecular mechanisms
involved in mitophagy initiation and execution, as well as the role
of mitophagy in Parkinson Disease, cardiac aging, and skeletal
muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively
describes the role of autophagy in human diseases, delivering
coverage of the antitumor and protumor roles of autophagy; the
therapeutic inhibition of autophagy in cancer; and the duality of
autophagy's effects in various cardiovascular, metabolic, and
neurodegenerative disorders. Volume 6: Regulation of Autophagy and
Selective Autophagy. Provides coverage of the mechanisms of
regulation of autophagy; intracellular pathogen use of the
autophagy mechanism; the role of autophagy in host immunity; and
selective autophagy. Volume 7: Role of Autophagy in Therapeutic
Applications. Provides coverage of the latest developments in
autophagosome biogenesis and regulation; the role of autophagy in
protein quality control; the role of autophagy in apoptosis;
autophagy in the cardiovascular system; and the relationships
between autophagy and lifestyle. Volume 8: Autophagy and Human
Diseases. Reviews recent advancements in the molecular mechanisms
underlying a large number of genetic and epigenetic diseases and
abnormalities, and introduces new, more effective therapeutic
strategies, in the development of targeted drugs and programmed
cell death, providing information that will aid on preventing
detrimental inflammation. Volume 9: Necrosis and Inflammation in
Human Diseases. Emphasizes the role of Autophagy in necrosis and
inflammation, explaining in detail the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of Omegasomes to autophagosomes.
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