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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 6Regulation of Autophagy and Selective Autophagy (Hardcover)
Loot Price: R3,758
Discovery Miles 37 580
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 6Regulation of Autophagy and Selective Autophagy (Hardcover)
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Volume 6 provides coverage of the mechanisms of regulation of
autophagy; intracellular pathogen use of the autophagy mechanism;
the role of autophagy in host immunity; and selective autophagy.
Attention is given to a number of mechanistic advances in the
understanding of regulation, particularly the importance of
nutrient availability; microRNAs; and cross-talk with other protein
degradation pathways. Intracellular pathogen repurposing of
autophagy for pathogenic benefit is also provided, with coverage of
Herpesvirus protein modulation of autophagy; the varicella-zoster
virus and the maintenance of homeostasis; and the relationship
between autophagy and the hepatitis b virus. The significance of
autophagy in host defense is elucidated, providing a specific focus
on facilitation of antigen presentation; participation in thymic
development; and the sharing of regulatory nodes with innate
immunity. Selective autophagy for the degradation of mitochondria
and endocytosed gap junctions are also explored. This book is an
asset to newcomers as a concise overview of the regulation of
autophagy, its role in host defense and immunity, and selective
autophagy, while serving as an excellent reference for more
experienced scientists and clinicians looking to update their
knowledge. Volumes in the Series Volume 1: Molecular Mechanisms.
Elucidates autophagy's association with numerous biological
processes, including cellular development and differentiation,
cancer, immunity, infectious diseases, inflammation, maintenance of
homeostasis, response to cellular stress, and degenerative diseases
such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral
sclerosis, and prion diseases. Volume 2: Role in General Diseases.
Describes the various aspects of the complex process of autophagy
in a myriad of devastating human diseases, expanding from a
discussion of essential autophagic functions into the role of
autophagy in proteins, pathogens, immunity, and general diseases.
Volume 3: Role in Specific Diseases. Explores the role of autophagy
in specific diseases and developments, including: Crohn's Disease,
Gaucher Disease, Huntington's Disease, HCV infection,
osteoarthritis, and liver injury, with a full section devoted to
in-depth exploration of autophagy in tumor development and cancer,
as well as the relationship between autophagy and apoptosis. Volume
4: Mitophagy. Presents detailed information on the role of
mitophagy, the selective autophagy of mitochondria, in health and
disease, by delivering an in-depth treatment of the molecular
mechanisms involved in mitophagy initiation and execution, as well
as the role of mitophagy in Parkinson Disease, cardiac aging, and
skeletal muscle atrophy. Volume 5: Role in Human Diseases.
Comprehensively describes the role of autophagy in human diseases,
delivering coverage of the antitumor and protumor roles of
autophagy; the therapeutic inhibition of autophagy in cancer; and
the duality of autophagy's effects in various cardiovascular,
metabolic, and neurodegenerative disorders. Volume 6: Regulation of
Autophagy and Selective Autophagy. Provides coverage of the
mechanisms of regulation of autophagy; intracellular pathogen use
of the autophagy mechanism; the role of autophagy in host immunity;
and selective autophagy. Volume 7: Role of Autophagy in Therapeutic
Applications. Provides coverage of the latest developments in
autophagosome biogenesis and regulation; the role of autophagy in
protein quality control; the role of autophagy in apoptosis;
autophagy in the cardiovascular system; and the relationships
between autophagy and lifestyle. Volume 8: Autophagy and Human
Diseases. Reviews recent advancements in the molecular mechanisms
underlying a large number of genetic and epigenetic diseases and
abnormalities, and introduces new, more effective therapeutic
strategies, in the development of targeted drugs and programmed
cell death, providing information that will aid on preventing
detrimental inflammation. Volume 9: Necrosis and Inflammation in
Human Diseases. Emphasizes the role of Autophagy in necrosis and
inflammation, explaining in detail the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of Omegasomes to autophagosomes.
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