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Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > Cytology

International Review of Cytology, Volume 200 (Hardcover): Kwang W. Jeon International Review of Cytology, Volume 200 (Hardcover)
Kwang W. Jeon
R5,287 Discovery Miles 52 870 Ships in 12 - 17 working days

International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Key Features
* Cell Biology of Aluminum Toxicity and Tolerance in Higher Plants
* Gonadal Development in Mammals at the Cellular and Molecular Levels
* The Chlorella Hexose/H+-Symporters
* Mechanisms of Early Neural Crest Development: From Cell Specification to Migration
* Regulation and Expression of Metazoan Unconventional Myosins

Fine Needle Aspiration Cytology - 100 Interesting Cases (Paperback, 1st ed. 2020): Pranab Dey Fine Needle Aspiration Cytology - 100 Interesting Cases (Paperback, 1st ed. 2020)
Pranab Dey
R3,438 Discovery Miles 34 380 Ships in 12 - 17 working days

This book discusses a broad selection of interesting cases of fine needle aspiration cytology (FNAC), which offer valuable insights into the diagnosis of cytology cases in routine practice. It provides the salient clinical history along with representative microphotographs of the routine smears. The content is divided into 100 chapters, with each chapter covering an individual case in detail. The book also addresses immunocytochemistry and other ancillary techniques that can help to diagnose lesions. Richly illustrated with more than 900 images, the book offers a valuable guide to diagnosis and self-evaluation for students/trainees/examinees of pathology and cytology practitioners alike.

Naturally Occurring Chemicals against Alzheimer's Disease (Paperback): Tarun Belwal, Seyed Mohammad Nabavi, Seyed Fazel... Naturally Occurring Chemicals against Alzheimer's Disease (Paperback)
Tarun Belwal, Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Ahmad Reza Dehpour, Samira Shirooie
R4,621 Discovery Miles 46 210 Ships in 12 - 17 working days

Naturally Occurring Chemicals against Alzheimer's Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer's disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations.

Signal Transduction and Human Disease (Hardcover, New): T. Finkel Signal Transduction and Human Disease (Hardcover, New)
T. Finkel
R5,344 Discovery Miles 53 440 Ships in 12 - 17 working days

The past few years have witnessed rapid progress in the characterization of mechanisms that underlie the generation and processing of inter- and intracellular signals. While there have been significant corollary advances in the area of signaling in disease processes, there is as yet no single resource that connects these advances with an understanding of disease processes and applications for novel therapeutics. Collecting chapters from the leading experts in their respective fields, editors Toren Finkel and Silvio Gutkind deliver a much-needed introduction to signaling and a fruitful discussion of promising directions for future research.

Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease’s manifestations and current treatment options. Following this introduction, the authors present an in-depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:

  • Cardio-Pulmonary Disease
  • Oncology
  • Endocrinology
  • Infectious Disease
  • Allergy/Rheumatology
  • Neurology/Psychiatry

Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.

Biased Signaling in Physiology, Pharmacology and Therapeutics (Hardcover): Brian J Arey Biased Signaling in Physiology, Pharmacology and Therapeutics (Hardcover)
Brian J Arey
R3,108 R2,776 Discovery Miles 27 760 Save R332 (11%) Ships in 12 - 17 working days

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

Cytokine Regulation of Humoral Immunity - Basic & Clinical Aspects (Hardcover): CM Snapper Cytokine Regulation of Humoral Immunity - Basic & Clinical Aspects (Hardcover)
CM Snapper
R10,904 Discovery Miles 109 040 Ships in 12 - 17 working days

Basic and clinical scientists with an interest in how cytokines regulate the production of antibody, and the selective expression of distinct antibody classes in response to microbial and other antigenic challenges, now have a single, comprehensive and timely volume covering this complex field. Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects uniquely focuses on the impact of the cytokine network on the humoral immune response, as well as its implications for the evolving field of cytokine-based medical therapeutics. With introductory chapters on basic B lymphocyte biology, a systematic and detailed review of the major B cell active cytokines, and discussions on cytokine regulation of normal and pathogenic humoral immune states, this highly referenced book will serve as a valuable source of information for both students and seasoned investigators active in multiple branches of basic and clinical immunology.

Formulation of Monoclonal Antibody Therapies - From Lab to Market (Paperback): Amal Ali Elkordy Formulation of Monoclonal Antibody Therapies - From Lab to Market (Paperback)
Amal Ali Elkordy
R3,592 Discovery Miles 35 920 Ships in 12 - 17 working days

Formulation of Monoclonal Antibody Therapies: From Lab to Market covers a wide range of topics about therapeutic monoclonal antibodies (mAbs) with a focus on formulation aspects. Therapeutic monoclonal antibodies are used for treatment of chronic diseases. It brings together a comprehensive knowledge in one accessible volume. Starting with foundational information on monoclonal antibodies, the book then discusses the importance of biopharmaceutical products, monoclonal antibodies and biosimilars in treatment of chronic diseases, pharmaceutical aspects of mAbs, and how it can be administered. It also covers the industrial point of view and the clinical application of mAbs including in oncology, general medicine, rheumatology, hematology, dermatology, gastrointestinal tract, metabolic diseases, and dentistry. Formulation of Monoclonal Antibody Therapies: From Lab to Market is essential reading for researchers in biotechnology and biopharmaceutical fields, academics and pharmaceutical industrial scientists, and university students in pharmaceutical and biopharmaceutical sciences.

Biotechnology of Microbial Enzymes - Production, Biocatalysis and Industrial Applications (Paperback): Goutam Brahmachari,... Biotechnology of Microbial Enzymes - Production, Biocatalysis and Industrial Applications (Paperback)
Goutam Brahmachari, Arnold L. Demain, Jose L Adrio
R2,948 Discovery Miles 29 480 Ships in 12 - 17 working days

Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. Applications of microbial enzymes in food, feed, and pharmaceutical industries are given particular emphasis. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last 20 years have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book.

Dyneins - Structure, Biology and Disease (Paperback): Stephen M. King Dyneins - Structure, Biology and Disease (Paperback)
Stephen M. King
R3,869 Discovery Miles 38 690 Ships in 12 - 17 working days

Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

Regulatory T Cells in Health and Disease, Volume 136 (Hardcover): Adrian Liston Regulatory T Cells in Health and Disease, Volume 136 (Hardcover)
Adrian Liston
R3,819 Discovery Miles 38 190 Ships in 12 - 17 working days

Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

Growth Hormone in Health and Disease, Volume 138 (Hardcover): F. F. Casanueva Growth Hormone in Health and Disease, Volume 138 (Hardcover)
F. F. Casanueva
R3,812 Discovery Miles 38 120 Ships in 12 - 17 working days

This volume of Progress in Molecular Biology and Translational Science focuses on the growth hormone in health and disease.

The Mast Cell - A Multifunctional Effector Cell (Paperback, 1st ed. 2019): Domenico Ribatti The Mast Cell - A Multifunctional Effector Cell (Paperback, 1st ed. 2019)
Domenico Ribatti
R2,886 Discovery Miles 28 860 Ships in 10 - 15 working days

Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 7Role of Autophagy in Therapeutic... Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 7Role of Autophagy in Therapeutic Applications (Hardcover)
M. A. Hayat
R3,663 Discovery Miles 36 630 Ships in 12 - 17 working days

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 7 provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; and the role of autophagy in apoptosis. Attention is given to autophagy in the cardiovascular system, with particular insights into the role of autophagy in atherosclerosis and the distinctive behavior of autophagy in the sinoatrial node. Cutting-edge findings in the relationships between autophagy and lifestyle are explored with the regulation of macroautophagy in response to exercise, as well as the promotion of carcinogenesis via autophagy in response to cigarette smoking. Volume 7 highlights the importance of understanding the role of autophagy in context, as the complexity of autophagic function becomes increasingly clear. Autophagy may be differentially regulated, and may perform distinctive cell-specific functions even within a single tissue. The overall significance of autophagy thus cannot be oversimplified, and must be explored with granular detail of the specific role, function, and area of impact. This book is an asset to newcomers as a concise overview of the complex significance of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

Phosphoinositides I: Enzymes of Synthesis and Degradation (Hardcover, 2012 ed.): Tamas Balla, Matthias Wymann, John D. York Phosphoinositides I: Enzymes of Synthesis and Degradation (Hardcover, 2012 ed.)
Tamas Balla, Matthias Wymann, John D. York
R4,431 Discovery Miles 44 310 Ships in 10 - 15 working days

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Imaging Flow Cytometry - Methods and Protocols (Hardcover, 1st ed. 2016): Natasha S. Barteneva, Ivan A. Vorobjev Imaging Flow Cytometry - Methods and Protocols (Hardcover, 1st ed. 2016)
Natasha S. Barteneva, Ivan A. Vorobjev
R4,556 Discovery Miles 45 560 Ships in 10 - 15 working days

This detailed volume for the first time explores techniques and protocols involving quantitative imaging flow cytometry (IFC), which has revolutionized our ability to analyze cells, cellular clusters, and populations in a remarkable fashion. Beginning with an introduction to technology, the book continues with sections addressing protocols for studies on the cell nucleus, nucleic acids, and FISH techniques using an IFC instrument, immune response analysis and drug screening, IFC protocols for apoptosis and cell death analysis, as well as morphological analysis and the identification of rare cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Imaging Flow Cytometry: Methods and Protocols will be a critical source for all laboratories seeking to implement IFC in their research studies.

Caveolins and Caveolae - Roles in Signaling and Disease Mechanisms (Hardcover, 2012): Jean Francois Jasmin, Philippe Frank,... Caveolins and Caveolae - Roles in Signaling and Disease Mechanisms (Hardcover, 2012)
Jean Francois Jasmin, Philippe Frank, Michael P Lisanti
R4,403 Discovery Miles 44 030 Ships in 10 - 15 working days

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

Cytology - Diagnostic Principles and Clinical Correlates (Hardcover, 5th edition): Edmund S. Cibas, Barbara S. Ducatman Cytology - Diagnostic Principles and Clinical Correlates (Hardcover, 5th edition)
Edmund S. Cibas, Barbara S. Ducatman
R4,394 Discovery Miles 43 940 Ships in 12 - 17 working days

Concise yet comprehensive, Cytology: Diagnostic Principles and Clinical Correlates is a practical guide to the diagnostic interpretation of virtually any cytological specimen you may encounter. This highly useful bench manual covers all organ systems and situations in which cytology is used, including gynecologic, non-gynecologic, and FNA samples, with an in-depth differential diagnosis discussion for all major entities. As with previous editions, the revised 5th Edition focuses on practical issues in diagnosis and the use of cytology in clinical care, making it ideal for both trainee and practicing pathologists. Uses easy-to-read, bulleted text to provide a quick review of key differential diagnoses, indications and methods, cytomorphologic features, clinical pearls, and tissue acquisition protocols for specific entities. Includes coverage of patient management in discussions of pertinent clinical features and emphasizes clinical correlation throughout. Examines the role of immunohistochemistry, flow cytometry, and molecular biology in resolving difficulties in interpretation and diagnosis. Features more than 550 full-color illustrations that provide a real-life perspective of a full range of cytologic findings. Discusses hot topics such as new diagnostic biomarkers and their utility in differential diagnosis, the latest Bethesda System classifications/terminology, new techniques, and new adjunct tests. Provides an in-depth analysis of common diagnostic pitfalls to assist with daily sign-out and reporting. Includes a video on how to perform fine needle aspiration biopsy, from the patient interview and precautions to demonstration of techniques. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Allosteric Modulation of G Protein-Coupled Receptors (Paperback): Robert Laprairie Allosteric Modulation of G Protein-Coupled Receptors (Paperback)
Robert Laprairie
R3,026 Discovery Miles 30 260 Ships in 12 - 17 working days

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies.

Autophagy in Health and Disease (Paperback, 2nd edition): Beverly Rothermel, Abhinav Diwan Autophagy in Health and Disease (Paperback, 2nd edition)
Beverly Rothermel, Abhinav Diwan
R3,965 Discovery Miles 39 650 Ships in 12 - 17 working days

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study.

Manipulation of Stem Cells for Disease Benefits (Hardcover): Travis S. Mason Manipulation of Stem Cells for Disease Benefits (Hardcover)
Travis S. Mason
R6,388 R4,823 Discovery Miles 48 230 Save R1,565 (24%) Ships in 12 - 17 working days

This collection of articles deals with the benefits of different types of stem cells sources, use, manipulation, and aspects for the treatment of chronic diseases. Topics include the role of calcium channel pathway/s in the regulation of neural stem cell differentiation; the evolutionary roles of the totipotent, pluripotent, or even multipotent stem cells; the derivations of multipotent MSCs; and potential canine-derived stem cell therapies for dogs. The scope of the book also provokes further studies into other topics, such as MSC differentiation into hepatocytes and the involvement of these cells with microRNA-133 in type 1 diabetes; the role of Vitronectin in the differentiation into endoderm; the extent to which the stemness of dental pulp stem cells might be useful; PBMCs as a source for pluripotent stem cells; yoga in possible synergy with the finding that bone marrow stromal cells provide relief from a laboratory reagent used as drug-mediated pain in spinal cord injury.

Epigenetic Cancer Therapy (Hardcover): Steven Gray Epigenetic Cancer Therapy (Hardcover)
Steven Gray
R3,560 R2,851 Discovery Miles 28 510 Save R709 (20%) Ships in 12 - 17 working days

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

Disease Pathways - An Atlas of Human Disease Signaling Pathways (Paperback): Anastasia Nesterova, Anton Yuryev, Eugene Klimov,... Disease Pathways - An Atlas of Human Disease Signaling Pathways (Paperback)
Anastasia Nesterova, Anton Yuryev, Eugene Klimov, Maria Zharkova, Maria Shkrob, …
R3,083 Discovery Miles 30 830 Ships in 12 - 17 working days

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein-protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy (Paperback): Loutfy H. Madkour Nucleic Acids as Gene Anticancer Drug Delivery Therapy (Paperback)
Loutfy H. Madkour
R4,537 R4,101 Discovery Miles 41 010 Save R436 (10%) Ships in 12 - 17 working days

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

Netter's Essential Biochemistry (Paperback): Peter Ronner Netter's Essential Biochemistry (Paperback)
Peter Ronner
R1,350 Discovery Miles 13 500 Ships in 12 - 17 working days

Concise writing, a focus on clinical applications, and superb illustrations make Netter's Essential Biochemistry, by Peter Ronner, PhD, the perfect choice for a basic understanding of biochemistry.. A single expert voice, informed by the insights of a team of reviewers, provides continuity throughout the text, presenting essentials of biochemical principles step by step. Summary diagrams help you grasp key concepts quickly, and end-of-chapter questions reinforce key concepts. Provides a highly visual, reader-friendly approach to the challenging area of biochemistry. Integrates the clinical perspective throughout the text, giving context and meaning to biochemistry. Frames every chapter with helpful synopses and summaries, and ends each chapter with review questions that reinforce major themes. Illustrates key concepts with beautifully clear drawings and diagrams of biochemical processes which are supplemented with art from the renowned Netter collection, bridging basic sciences with clinical practice. Student ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book as well as new materials (outlined above) designed to produce a more rounded learning experience.

Reproducibility in Biomedical Research - Epistemological and Statistical Problems (Paperback): Erwin B. Montgomery Reproducibility in Biomedical Research - Epistemological and Statistical Problems (Paperback)
Erwin B. Montgomery
R2,801 R2,554 Discovery Miles 25 540 Save R247 (9%) Ships in 12 - 17 working days

Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of science and medicine will find the arguments and explorations a valuable addition to their libraries.

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