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Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > Cytology

From Ion Channels to Cell-to-Cell Conversations (Hardcover, 1997 ed.): Ramon Latorre, Juan Carlos Saez From Ion Channels to Cell-to-Cell Conversations (Hardcover, 1997 ed.)
Ramon Latorre, Juan Carlos Saez
R8,692 Discovery Miles 86 920 Ships in 10 - 15 working days

Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel forming molecules."

Neural Cell Specification - Molecular Mechanisms and Neurotherapeutic Implications - Proceedings of the Third Altschul... Neural Cell Specification - Molecular Mechanisms and Neurotherapeutic Implications - Proceedings of the Third Altschul Symposium Held in Saskatoon, Canada, May 12-14, 1994 (Hardcover)
B.H.J. Juurlink, Etc
R2,670 Discovery Miles 26 700 Ships in 10 - 15 working days

Pattern Formation in the Vertebrate CNS: Hox Gene Function and the Development of the Head; M. Mark, et al. Genetic Mechanisms Responsible for Pattern Formation in the Vertebrate Hindbrain: Regulation of Hoxb1; M. Studer, et al. Pax Genes as Pleiotropic Regulators of Embryonic Development; P. Tremblay, et al. Introduction and the Generation of Regional and Cellular Diversity in the Developing Mammalian Brain; A.S. LaMantia. Genetic Determinants of Neural Cell Fate: Potential Role of Homeobox Genes in Neural Cell Differentiation; M. Gulisano, et al. Multiple Roles for Proneural Genes in Drosophila Neurogenesis; A.P. Jarman, Y.N. Jan. Genetic Analysis of Neuronal Migration in The Nematode Caenorhabditis elegans; G. Garriga. Induction and Differentiation of Motor Neurons; S.L. Pfaff, et al. Neural Cell Differentiation: Neuronal Development in the Rat Sympathoadrenal Lineage; S.J. Birren, et al. Specification of Cell Fate in the Vertebrate Retina; C.P. Austin. Neurotrophins and Trk Receptors in Hippocampal Development; D. Collazo, R. McKay. 8 additional articles. Index.

Breast Cytology In Clin. Pract (Hardcover): J. Lamb Breast Cytology In Clin. Pract (Hardcover)
J. Lamb
R1,026 Discovery Miles 10 260 Ships in 9 - 15 working days

This book will be of importance in breast cancer diagnosis where cytology has become a mandatory procedure in the large number of cases where doubt remains. The book aims to provide the reader with up-to-date information on the techniques of breast cytologic sampling and interpretation. The text is accompanied by colour and black and white illustrations and includes practical procedures and pathological findings.

Cell Proliferation and Cytogenesis in the Mouse Hippocampus (Paperback): Kyrill Yu Reznikov Cell Proliferation and Cytogenesis in the Mouse Hippocampus (Paperback)
Kyrill Yu Reznikov
R2,841 Discovery Miles 28 410 Ships in 10 - 15 working days

In the present work, processes of cell proliferation, cell death, neurogenesis, and gliogenesis in the mouse hippocampus were studied. The mapping of distribution of hippocampal mitoses and counting of their number allowed a more precise definition of the data concerning the disposition and age reduction of proliferative sites in Ammon's horn and the dentate gyrus in the mouse. As a result, the following generalized scheme of development and age reduction of the germinal zones in the mouse hippocampus has been suggested. 1. Ammon's horn a) The ventricular zone, from the beginning of formation of the hippocampus (Ell) until E20 b) The suprafimbrial zone, from El6 until P7 2. Dentate gyrus a) The prime germinal zone ("the anlage of the dentate gyrus" of Stanfield and CowanI979b), from E15 until P3 b) The proliferative zone of the hilus, from P3 until Pl4 c) The subgranular zone, from P3 until adult age The adduced scheme needs some comments: 1. In the hippocampus (as well as in other formations of the developing brain), primary precursors of all types of cells of neuroectodermal origin are represented by cells of the ventricular zone. They give rise to cells of secondary germinal zones in the dentate gyrus and Ammon's horn and are direct precursors of the majority (if not of all) neuronal cells in Ammon's horn, the earliest originating generations of neurons in the dentate gyrus, hippocampal radial glial cells, and, evidently, of a considerable part of astroblasts and oligodendroblasts in Ammon's horn.

Molecular Basis of Lymphokine Action (Hardcover, 1987 ed.): David R. Webb, Carl W. Pierce, Stanley Cohen Molecular Basis of Lymphokine Action (Hardcover, 1987 ed.)
David R. Webb, Carl W. Pierce, Stanley Cohen
R5,945 Discovery Miles 59 450 Ships in 10 - 15 working days

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor."

The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology... The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology (Paperback, 1st ed. 2020)
Andrew S. Field, Wendy A. Raymond, Fernando Schmitt
R1,331 R1,261 Discovery Miles 12 610 Save R70 (5%) Ships in 9 - 15 working days

This text describes a system of reporting breast fine needle aspiration biopsy that uses five clearly defined categories, each described by a specific term and each with a specific risk of malignancy. The five categories are insufficient/inadequate, benign, atypical, suspicious of malignancy and malignant. Each category has a risk of malignancy and is linked to management recommendations, which include several options because it is recognized that diagnostic infrastructure, such as the availability of core needle biopsy and ultrasound guidance, vary between developed and low and middle income countries. This text includes key diagnostic cytological criteria for each of the many lesions and tumors found in the breast. The cytopathology of specific lesions is illustrated with high quality photomicrographs with clear figure descriptions. Chapters also discuss current and potential future ancillary tests, liquid based cytology, nipple cytology and management. An additional chapter provides an overview of an approach to the diagnosis of direct smears of breast fine needle aspiration biopsies. The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology provides a clear logical approach to the diagnosis and categorization of breast lesions by FNAB cytology, and aims to facilitate communication with breast clinicians, further research into breast cytopathology and related molecular pathology, and improve patient care.

Cell Biology Playing Cards - Cell Biology Playing Cards: Art Cards Box of 12 Decks (Bulk) (Cards): Thomas D. Pollard, William... Cell Biology Playing Cards - Cell Biology Playing Cards: Art Cards Box of 12 Decks (Bulk) (Cards)
Thomas D. Pollard, William C. Earnshaw, Graham Johnson, Jennifer Lippincott-Schwartz
R2,269 Discovery Miles 22 690 Ships in 12 - 17 working days

Fun and educational, these unique playing cards are beautifully illustrated with detailed cells and cellular structures - perfect for science lovers and cell biologists of all ages! Card faces features favorite illustrations from the textbook Cell Biology by Thomas D. Pollard et al. - from the clathrin triskelion and its three-fold symmetry on the 3 to mitotic chromosome structure on the Queen! Standard 52-card deck with illustrations of endosomes and lysosome, mother and daughter centrioles, membrane traffic, eukaryotic phylogenetic tree, three cytoskeletal polymers, and more. Jokers feature illustrations of autophagy (red joker) and ribosome, V-type ATPase, CRISPR/Cas, bacterium (black joker). Fourteen different card faces in all featuring the well-loved cellular illustrations of Graham Johnson. Includes 12 individual decks of cards.

Phagocytosis - Overview, History and Role in Human Health  and Disease (Hardcover): Carlos Rosales Phagocytosis - Overview, History and Role in Human Health and Disease (Hardcover)
Carlos Rosales
R5,386 R4,798 Discovery Miles 47 980 Save R588 (11%) Ships in 12 - 17 working days

Phagocytosis is an elegant, but complex process that cells use for the ingestion and elimination of particles larger than 5 mm in diameter. Unicellular organisms use phagocytosis to eat, while complex pluricellular animals have special phagocytic cells, which can phagocytize microbial pathogens, foreign toxic substances, and apoptotic cells. The Russian scientist Elie Metchnikoff originally described phagocytosis in the late 19th century. The scientific community of the time strongly opposed phagocytosis as part of their defense mechanisms, since the view was that only humoral elements were responsible for immunity. The importance of this cellular process has become evident with time thanks to the efforts of many dedicated researchers. Today, phagocytosis is recognized as a fundamental process not only for immunity, but also for tissue homeostasis. Because phagocytosis is a very complex process, its molecular bases are not completely known. This book represents an effort to introduce our present understanding of phagocytosis through the contribution of several brilliant scientists that actually investigate phagocytosis on a daily basis. This book describes the history of phagocytosis and then the various steps of the phagocytic process from initial cell contact to phagosome formation, where the phagocytized particle is destroyed. Each chapter deals with one of these steps and emphasizes the molecules that participate at that step. The authors begin by describing the difficult origins of phagocytosis and how the cellular theory was finally recognized to be as important as the humoral theory of immunity. Next, the chapter "Receptor Signaling During Phagocytosis" talks about the signaling pathways of the major groups of phagocytic receptors, namely receptors for antibodies and complement. Then, the chapter The Role of Phosphoinositides in the Formation and Maturation of Phagosomes describes how these different membrane phospholipds regulate the changes in membrane composition during the process of phagocytosis. The following chapters deal with the mechanics of phagosome formation and membrane traffic for phagosome maturation. So, the chapter "Phagosome Formation and Sealing: A Physical Point of View" tells us about the cytoskeleton changes that bring about the closure of the new phagosome. The chapter Vesicular Trafficking: Golgi to Plasma Membrane describes the movement of internal membranes to the plasma membrane to allow the formation of the phagosome. The chapter Retinal Pigment Epithelial Cells: Super Phagocytes with a Rhythm describes an important example of how phagocytosis contributes to homeostasis. In the eye, the retinal pigment epithelium cells specifically phagocytize the photosensitive outer segment of photoreceptor cells following a diurnal rhythm. This contributes to the maintenance of a healthy retina. Finally, the chapter How Do Microbial Pathogens Escape from Phagocytosis? describes various mechanisms that some microbial pathogens have evolved to disrupt the phagocytic process and be able to survive in the host to perpetuate their infection. Each chapter can be read independently, but together all of the chapters offer a general view of phagocytosis. The book provides in this way a complete modern vision of this important biological function.

Liposomes - Historical, Clinical & Molecular Perspectives (Hardcover): Benjamin R. Pearson Liposomes - Historical, Clinical & Molecular Perspectives (Hardcover)
Benjamin R. Pearson
R6,358 R5,743 Discovery Miles 57 430 Save R615 (10%) Ships in 12 - 17 working days

Chapter One is addressed to a comprehensive revision of the bibliography regarding the emergence of liposomes and the first steps in their design, the type of systems (components and structures), their classification and properties. Chapter Two discusses the possibility of creating living synthetic cells. Chapter Three provides an overview of the development and application of liposomes in biomedical sciences, with special emphasis on recent advances in the investigation of multifunctional liposomes that target cells and cellular organelles with a single delivery system. In Chapter Four, the authors review the mechanisms of drug transport through the BBB using liposomes, and the design strategies for optimum liposomal properties. In Chapter Five, the development rationales and structural types of pH-sensitive liposomes is discussed Chapter Six presents the characteristic, classification and preparation methods of liposomes. To develop liposomal drug delivery system, functional liposomes including antibody-conjugating liposomes known as immunoliposomes and stimuli-triggered liposomes such as pH- and thermo-sensitive liposomes have been investigated in Chapter Seven. Chapter Eight covers the use of thermosensitive liposomes for drug delivery and cancer therapy, because the side-effects of anticancer drugs are restrained and drug release can be controlled in combination with local hyperthermia. In Chapter Nine, the authors summarise the potential of OMLs as a novel adjuvant and antigen delivery vehicle for induction of encased antigen-specific strong T cell immunity. Chapter Ten presents the recent advances of liposomes in drug and vaccine delivery and shed light to the application of DSC to thermodynamic characterisation of liposomal delivery platforms. Chapter Eleven focuses on various liposomal delivery systems that are currently being explored to overcome the anatomical and physiological obstacles to improve the delivery efficiency of BNCT to brain glioma cells.

Cell Transplantation - New Research (Paperback): David J. Belgaris, Alyson N. Savarese Cell Transplantation - New Research (Paperback)
David J. Belgaris, Alyson N. Savarese
R1,805 R1,686 Discovery Miles 16 860 Save R119 (7%) Ships in 12 - 17 working days

In this book, the authors gather and present topical research in the study of cell transplantation. Topics discussed in this compilation include cell transplantation in chronic kidney disease; dendritic cells in allogenic hematopoietic cell transplantation; islet cell transplantation replacing beta cells that produce insulin in a diabetes cure; ocular surface reconstruction using cellular therapies; cell therapy on ischemic flaps; and, new therapeutic strategy for veno-occlusive disease after hematopoietic stem cell transplantation.

Trends in Stem Cell Research (Hardcover, Illustrated Ed): Erik V Greer Trends in Stem Cell Research (Hardcover, Illustrated Ed)
Erik V Greer
R6,215 R3,892 Discovery Miles 38 920 Save R2,323 (37%) Ships in 12 - 17 working days

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This new book brings together leading research from throughout the world in this frontier field.

Human Stem Cell Toxicology (Hardcover): James L. Sherley Human Stem Cell Toxicology (Hardcover)
James L. Sherley
R5,750 Discovery Miles 57 500 Ships in 10 - 15 working days

Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.

The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology - Definitions, Criteria and... The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology - Definitions, Criteria and Explanatory Notes (Paperback)
Martha Bishop Pitman, Lester James Layfield
R1,744 R1,646 Discovery Miles 16 460 Save R98 (6%) Ships in 9 - 15 working days

This text and the terminology developed by the Papanicolaou Society of Cytopathology (P.S.C.) represents an important advance in the field of pancreaticobiliary cytopathology. This textbook/atlas is designed to present a comprehensive and state of the art approach to the cytologic diagnosis and reporting of pancreaticobiliary lesions. Chapters address each of the diagnostic categories defined by the P.S.C. The definition of each category along with the clinical pathologic entities contained within the category are discussed along with specific cytologic criteria for inclusion of a cytologic specimen within the category. Each chapter is lavishly illustrated demonstrating diagnostic criteria and examples of lesions contained within the category. Additionally, appropriate ancillary testing is discussed and where appropriate illustrated. Each chapter concludes with a discussion of appropriate management as well as estimates of malignancy risk for the category. The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology: Definitions, Criteria, Ancillary Testing and Management will provide the reader with a unified approach to diagnosing and reporting interpretations of cytologic specimens obtained from the pancreaticobiliary tract. This text/atlas will serve as a reference guide for pathologists, surgeons, endoscopists and radiologists.

Kinase Inhibitors - Methods and Protocols (Hardcover, 2012 ed.): Bernhard Kuster Kinase Inhibitors - Methods and Protocols (Hardcover, 2012 ed.)
Bernhard Kuster
R4,429 Discovery Miles 44 290 Ships in 10 - 15 working days

Protein and lipid kinases are often the master regulators of cell signaling in eukaryotic systems. The human genome codes for more than 500 of these enzymes and their misregulation has been shown to be involved in the onset and progression of many diseases including cancer and inflammation. Therefore, small molecule kinase inhibitors have become important research tools for the elucidation of the many biological roles of kinases and their mechanisms of action. Kinase inhibitors thus also contribute significantly to the drug pipelines of the pharmaceutical and biotechnology industries and to the growing need to treat cancer and inflammation. In Kinase Inhibitors: Methods and Protocols, experts in kinase biology, drug discovery, and clinical research present a series of exemplary methods that can be used to address the many challenges facing scientists in the discovery and development of kinase inhibitors both for research and clinical use. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Kinase Inhibitors: Methods and Protocols aims to provide scientists with modern and relevant methods to accelerate or strengthen their research and drug discovery programs through the utilization of these vital regulators.

Understanding Breast Cancer - Cell Biology and Therapy (Paperback): Joel D.  Pardee Understanding Breast Cancer - Cell Biology and Therapy (Paperback)
Joel D. Pardee
R832 Discovery Miles 8 320 Ships in 10 - 15 working days

The mysterious disease of cancer, including breast cancer, has plagued mankind since the dawn of recorded history. Regarding the elusive cause of the disease, the "Father of Medicine," Hippocrates of Athens (460-377 BC), wrote that, "For instability is characteristic of the humours and so they may be easily altered by nature and by chance." The enigma has persisted until today. In 1971, then President Richard Nixon signed the National Cancer Act and declared a "War on Cancer." He believed the counsel of scientists and physicians that if sufficient resources were committed to the fight, cancer could be virtually eliminated within 5 years. The prophesy failed. Although mortality from a few cancers, most notably leukemias, has been significantly reduced, carcinomas, cancers of the epithelium, which account for 80% of cancer deaths, remain unchanged. While tremendous advances have taken place in our understanding of the molecular and cellular mechanisms operant in cancer, it has proven exceedingly difficult to prevent the occurrence or to halt the progress of the disease. The very best therapy remains early detection while the primary tumor is small and localized to a single site, followed by removal of the offending growth by surgery and/or radiation. The great challenge of finding a cure confronts us yet, and it is effective intervention at the molecular level that offers our best hope. We still must find the "magic bullet."

Nucleic Acids as Molecular Diagnostics (Hardcover): Andreas Keller, Eckart Meese Nucleic Acids as Molecular Diagnostics (Hardcover)
Andreas Keller, Eckart Meese
R2,940 Discovery Miles 29 400 Ships in 12 - 17 working days

By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.

Color Atlas of Cytology, Histology, and Microscopic Anatomy (Paperback, 4th edition, revised and enlarged): Wolfgang Kuhnel Color Atlas of Cytology, Histology, and Microscopic Anatomy (Paperback, 4th edition, revised and enlarged)
Wolfgang Kuhnel
R1,135 R1,014 Discovery Miles 10 140 Save R121 (11%) Ships in 12 - 17 working days

A proven classic. This timeless pocket atlas is the ideal visual companion to histology and cytology textbooks. First published in 1950 and translated into eight languages, Kuehnel's Pocket Atlas of Cytology, Histology and Microscopic Anatomy is a proven classic. The fully revised and updated fourth edition contains 745 full-color illustrations - almost 200 more than were included in the third edition. Superb, high-quality microphotographs and pathologic stains are accompanied by legends, informative texts, and numerous cross-references. Key features of the updated fourth edition: More than 700 high-quality illustrations using advanced techniques in histology and electron microscopy Practical, information Concise and focused text Key concepts and ideas illustrated in less than 550 pages Ideal for exam preparation, this world-class book is an indispensable visual study tool for medical, dental and biology students. It can also serve as an outstanding review and refresher text.

DNA Transfer to Cultured Cells (Paperback, New): K. Ravid DNA Transfer to Cultured Cells (Paperback, New)
K. Ravid
R5,014 Discovery Miles 50 140 Ships in 10 - 15 working days

DNA transfer to cultured cells
Edited by Katya Ravid and R. Ian Freshney
Rapid advances in DNA transfer technology have transformed many disciplines, ranging from molecular genetics to biotechnology. Scientists now have the means to introduce copies of genes into different cell types, then detect the expression of these genes in the cell. It is now possible to regulate cell growth that may lead to cancer, develop new biopharmaceuticals, and apply knowledge about the role of genes in cell processes to basic research in molecular genetics.
DNA Transfer to Cultured Cells is the first quick reference to all of the established techniques for the transfer of genetic material to cells in vitro. Featuring contributions by leading researchers in the field, this detailed guide walks the reader through a variety of DNA transfer methods, describes their application to specific cell types, and integrates aspects of molecular biology with tissue culture. Offering overviews and detailed protocols for the techniques under discussion in each of its sections, this book covers an exceptionally broad array of topics, including:
* Viral infection
* Electroporation
* Phosphate precipitation
* DEAE Dextran
* Liposomes
* Yeast artificial chromosomes (YACs)
* Whole chromosome transfer
* Enhanced expression.
Special sections at the end of each chapter list suppliers for necessary reagents and materials. This easy-to-use, self-contained guide addresses key developments of recent years as well as emerging trends in DNA transfer. For practical applications in cell biology, genetics, heredity, biotechnology, or evolution, DNA Transfer to Cultured Cells is a uniqueand unparalleled resource.

Forensic DNA Profiling Protocols (Hardcover, 1998 ed.): Patrick J. Lincoln Forensic DNA Profiling Protocols (Hardcover, 1998 ed.)
Patrick J. Lincoln
R2,924 Discovery Miles 29 240 Ships in 10 - 15 working days

It is now more than ten years since Dr. Alec Jeffreys (now Professor Sir Alec Jeffreys, FRS) reported in Nature that the investigation of certain minisatellite regions in the human genome could produce what he termed DNA fingerprints and provide useful information in the fields of paternity testing and forensic analysis. Since that time we have witnessed a revolution in the field of forensic identification. A total change of technology, from serological or electrophoretic analysis of protein polymorphisms to direct investigation of the underlying DNA polymorphisms has occurred in a short space of time. In addition, the evolution and development of the DNA systems themselves has been rapid and spectacular. In the last decade we have progressed from the multilocus DNA fing- prints, through single locus systems based on the same Southern blot RFLP technology, to a host of systems based on the PCR technique. These include Allele Specific Oligonucleotide (ASO)-primed systems detected by dot blots, the "binary" genotypes produced by mapping variations within VNTR repeats demonstrated by minisatellite variant repeat (MVR) analysis, and yet other fragment-length polymorphisms in the form of Short Tandem Repeat (STR) loci. Hand in hand with the increasing range of systems available has been the development of new instrumentation to facilitate their analysis and allow us to explore the possibilities of high volume testing in the form of mass scre- ing and offender databases.

Practical Immunocytochemistry in Diagnostic Cytology (Paperback, 1st ed. 2020): Eugenio Leonardo, Ricardo H. Bardales Practical Immunocytochemistry in Diagnostic Cytology (Paperback, 1st ed. 2020)
Eugenio Leonardo, Ricardo H. Bardales
R2,396 Discovery Miles 23 960 Ships in 10 - 15 working days

This book provides current information for a judicious use of conventional and molecular ICC markers performed in cytologic samples to help in the cost-effective diagnosis of superficial and deep-seated masses. By providing both an eminently practical information for appropriate technical preparation of cytologic samples and a systematic exposure of the immunophenotypic and biomolecular characteristics of normal and pathological cells, the reported morphological-molecular findings highlight the characteristics of different lesions that are useful for the practical solution of a particular differential diagnosis. Chapters include description of the cytomorphology followed by a practical ICC staining pattern for each entity. Cytologic materials include serous effusions, exfoliative cytology, fine needle aspiration cytology of superficial and deep-seated masses, and squash preparation from central nervous system masses. Practical Immunocytochemistry in Diagnostic Cytology serves as a valuable resource towards understanding critical differences between tests performed on tissue samples and those carried out on cytologic samples.

Human Cell Transformation - Advances in Cell Models for the Study of Cancer and Aging (Paperback, 1st ed. 2019): Johng S. Rhim,... Human Cell Transformation - Advances in Cell Models for the Study of Cancer and Aging (Paperback, 1st ed. 2019)
Johng S. Rhim, Anatoly Dritschilo, Richard Kremer
R4,386 Discovery Miles 43 860 Ships in 10 - 15 working days

This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Plant Cell Biology (Hardcover): Mark Harper Plant Cell Biology (Hardcover)
Mark Harper
R3,222 R2,785 Discovery Miles 27 850 Save R437 (14%) Ships in 10 - 15 working days
Adult Stem Cell Released Molecules - A Paradigm Shift to Systems Therapeutics (Hardcover): Greg Maguire Adult Stem Cell Released Molecules - A Paradigm Shift to Systems Therapeutics (Hardcover)
Greg Maguire
R4,381 Discovery Miles 43 810 Ships in 12 - 17 working days

Dr. Greg Maguire's thought-provoking book offers a radically new approach to the standard means of developing drugs through the use of the molecules that stem cells release. Emphasizing that living organisms operate through the collective actions of entities within and between all levels of the biological organism, including the quantum level, molecular level, and cellular level, for example, the argument is put forth that drug development, and medicine itself, must treat various indications by understanding and then treating the collective actions at the relevant levels that are found to be perturbed in that particular indication. Motivated by the recent successes in the fields of quantum collective electrodynamics and condensed matter physics, where systems level thinking has explained through mathematical and conceptual reasoning how these phenomenon work, and doing so with heuristic outcomes, Maguire argues that the same system level thinking must be applied to drug development and medicine. The interactive nature of these fundamental collective processes is at the core of developing systems therapeutics and, as such, challenges those that believe in fundamental reductionism, where understanding the components of the system will explain the system. During these times, fundamental reductionism is often used to explain diseases as the result of an aberration in a DNA sequence, and targeted approaches to drug development lead to the development of small molecules to specifically target only one pathway. Because of this, there is an understanding that diseases and other indications are multifactorial and often don't involve a genomic alteration; systems biology analysis should lead to systems therapeutics where multiple pathways, often at different levels of the organism, are targeted by the therapeutic aspects. The therapeutic development approach that Maguire explains is a result of reverse engineering endogenous adult stem cell function that serves to maintain and heal our tissues. Using the pools of molecules that different types of adult stem cells release, each pool of molecules being tissue specific for the indication to be treated, Maguire describes the systems therapeutic results. The book is divided into nine sections, each of which can be read as a standalone chapter and serve as a source of references on the particular topic. Although some of the topics use mathematical formulas, none of the material requires mathematical rigor in order to understand the concepts. The last chapter culminates in showing how the systems therapeutic approach using the molecules from adult stem cells is used to treat neurodegeneration.

Cytohistology with CD-ROM - Essential and Basic Concepts (Hardcover): Prabodh Gupta, Zubair Baloch Cytohistology with CD-ROM - Essential and Basic Concepts (Hardcover)
Prabodh Gupta, Zubair Baloch
R4,045 R3,470 Discovery Miles 34 700 Save R575 (14%) Ships in 12 - 17 working days

This book represents the essentials of diagnostic cytopathology. Clinical research has confirmed the efficacy of the cytologic method of disease diagnosis and it is now considered the definitive method for identifying a wide array of malignancies. Cytohistology: Essential and Basic Concepts comprehensively covers all the morphologic variations and landmarks in cells that can potentially signal disease. Morphologies in cancer are the primary focus but all potential changes in infectious and inflammatory disorders are also covered in detail. There is a separate section on molecular and other ancillary diagnostic techniques in cytopathology. Conceptual drawings presented in a pansystemic approach and incorporating state-of-the-art techniques show basic cytomorphologic features essential for interpretation of cytopathology specimens. Diagnostic pitfalls and challenging intellectual nuggets are also presented. A supplementary CD with images in a downloadable format is included.

Transcriptional and Translational Regulation of Stem Cells (Hardcover, 2013 ed.): Gary Hime, Helen Abud Transcriptional and Translational Regulation of Stem Cells (Hardcover, 2013 ed.)
Gary Hime, Helen Abud
R6,249 Discovery Miles 62 490 Ships in 10 - 15 working days

Stem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury. In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced. Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of differentiation could disrupt tissue homeostasis or repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of re

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