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Liposomes - Historical, Clinical & Molecular Perspectives (Hardcover)
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Liposomes - Historical, Clinical & Molecular Perspectives (Hardcover)
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Chapter One is addressed to a comprehensive revision of the
bibliography regarding the emergence of liposomes and the first
steps in their design, the type of systems (components and
structures), their classification and properties. Chapter Two
discusses the possibility of creating living synthetic cells.
Chapter Three provides an overview of the development and
application of liposomes in biomedical sciences, with special
emphasis on recent advances in the investigation of multifunctional
liposomes that target cells and cellular organelles with a single
delivery system. In Chapter Four, the authors review the mechanisms
of drug transport through the BBB using liposomes, and the design
strategies for optimum liposomal properties. In Chapter Five, the
development rationales and structural types of pH-sensitive
liposomes is discussed Chapter Six presents the characteristic,
classification and preparation methods of liposomes. To develop
liposomal drug delivery system, functional liposomes including
antibody-conjugating liposomes known as immunoliposomes and
stimuli-triggered liposomes such as pH- and thermo-sensitive
liposomes have been investigated in Chapter Seven. Chapter Eight
covers the use of thermosensitive liposomes for drug delivery and
cancer therapy, because the side-effects of anticancer drugs are
restrained and drug release can be controlled in combination with
local hyperthermia. In Chapter Nine, the authors summarise the
potential of OMLs as a novel adjuvant and antigen delivery vehicle
for induction of encased antigen-specific strong T cell immunity.
Chapter Ten presents the recent advances of liposomes in drug and
vaccine delivery and shed light to the application of DSC to
thermodynamic characterisation of liposomal delivery platforms.
Chapter Eleven focuses on various liposomal delivery systems that
are currently being explored to overcome the anatomical and
physiological obstacles to improve the delivery efficiency of BNCT
to brain glioma cells.
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