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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Ion Channel Regulation, Volume 33 (Hardcover)
Loot Price: R3,996
Discovery Miles 39 960
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Ion Channel Regulation, Volume 33 (Hardcover)
Series: Advances in Second Messenger and Phosphoprotein Research
Expected to ship within 10 - 15 working days
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Volume 33 reviews the current understanding of ion channel
regulation by signal transduction pathways. Ion channels are no
longer viewed simply as the voltage-gated resistors of
biophysicists or the ligand-gated receptors of biochemists. They
have been transformed during the past 20 years into signaling
proteins that regulate every aspect of cell physiology. In addition
to the voltage-gated channels, which provide the ionic currents to
generate and spread neuronal activity, and the calcium ions to
trigger synaptic transmission, hormonal secretion, and muscle
contraction, new gene families of ion channel proteins regulate
cell migration, cell cycle progression, apoptosis, and gene
transcription, as well as electrical excitability. Even the genome
of the lowly roundworm Caenorhabditis elegans encodes almost 100
distinct genes for potassium-selective channels alone. Most of
these new channel proteins are insensitive to membrane potential,
yet in humans, mutations in these genes disrupt development and
increase individual susceptibility to debilitating and lethal
diseases.
How do cells regulate the activity of these channels? How might we
restore their normal function? In Ion Channel Regulation, many of
the experts who pioneered these discoveries provide detailed
summaries of our current understanding of the molecular mechanisms
that control ion channel activity.
Key Features
* Reviews brain functioning at the fundamental, molecular
level
* Describes key systems that control signaling between and within
cells
* Explains how channels are used to stimulate growth and changes to
activity of the nucleus and genome
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