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Quantitative Biology of Endocytosis (Hardcover)
Loot Price: R1,661
Discovery Miles 16 610
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Quantitative Biology of Endocytosis (Hardcover)
Series: Colloquium Series on Quantitative Cell Biology
Expected to ship within 10 - 15 working days
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Clathrin-mediated endocytosis (CME) is a ubiquitous internalization
process in eukaryotic cells. It consists of the formation of an
approximately 50-nm diameter vesicle out of a flat membrane.
Genetics, biochemistry, and microscopy experiments performed in the
last four decades have been instrumental to discover and
characterize major endocytic proteins in yeast and mammals.
However, due to the highly dynamic nature of the endocytic assembly
and its small size, many questions remain unresolved: how are
endocytic proteins organized spatially and dynamically? How are
forces produced and how are their directions controlled? How do the
biochemical activities of endocytic proteins and the membrane shape
and mechanics regulate each other? These questions are virtually
impossible to visualize or measure directly with conventional
approaches but thanks to new quantitative biology methods, it is
now possible to infer the mechanisms of endocytosis in exquisite
detail. This book introduces quantitative microscopy and
mathematical modeling approaches that have been used to count the
copy number of endocytic proteins, infer their localization with
nanometer precision, and infer molecular and physical mechanisms
that are involved in the robust formation of endocytic vesicles.
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