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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 5 Role in Human Diseases (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 5 Role in Human Diseases (Hardcover)
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Understanding the importance and necessity of the role of autophagy
in health and disease is vital for the studies of cancer, aging,
neurodegeneration, immunology, and infectious diseases.
Comprehensive and up-to-date, this book offers a valuable guide to
these cellular processes whilst inciting researchers to explore
their potentially important connections. Volume 5 comprehensively
describes the role of autophagy in human diseases, delivering
coverage of the antitumor and protumor roles of autophagy; the
therapeutic inhibition of autophagy in cancer; and the duality of
autophagy's effects in various cardiovascular, metabolic, and
neurodegenerative disorders. In spite of the increasing importance
of autophagy in the various pathophysiological conditions mentioned
above, this process remains underestimated and overlooked. As a
consequence, its role in the initiation, stability, maintenance,
and progression of these and other diseases remains poorly
understood. This book is an asset to newcomers as a concise
overview of the diverse disease implications of autophagy, while
serving as an excellent reference for more experienced scientists
and clinicians looking to update their knowledge. Volumes in the
Series Volume 1: Molecular Mechanisms. Elucidates autophagy's
association with numerous biological processes, including cellular
development and differentiation, cancer, immunity, infectious
diseases, inflammation, maintenance of homeostasis, response to
cellular stress, and degenerative diseases such as Alzheimer's,
Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion
diseases. Volume 2: Role in General Diseases. Describes the various
aspects of the complex process of autophagy in a myriad of
devastating human diseases, expanding from a discussion of
essential autophagic functions into the role of autophagy in
proteins, pathogens, immunity, and general diseases. Volume 3: Role
in Specific Diseases. Explores the role of autophagy in specific
diseases and developments, including: Crohn's Disease, Gaucher
Disease, Huntington's Disease, HCV infection, osteoarthritis, and
liver injury, with a full section devoted to in-depth exploration
of autophagy in tumor development and cancer, as well as the
relationship between autophagy and apoptosis. Volume 4: Mitophagy.
Presents detailed information on the role of mitophagy, the
selective autophagy of mitochondria, in health and disease, by
delivering an in-depth treatment of the molecular mechanisms
involved in mitophagy initiation and execution, as well as the role
of mitophagy in Parkinson Disease, cardiac aging, and skeletal
muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively
describes the role of autophagy in human diseases, delivering
coverage of the antitumor and protumor roles of autophagy; the
therapeutic inhibition of autophagy in cancer; and the duality of
autophagy's effects in various cardiovascular, metabolic, and
neurodegenerative disorders. Volume 6: Regulation of Autophagy and
Selective Autophagy. Provides coverage of the mechanisms of
regulation of autophagy; intracellular pathogen use of the
autophagy mechanism; the role of autophagy in host immunity; and
selective autophagy. Volume 7: Role of Autophagy in Therapeutic
Applications. Provides coverage of the latest developments in
autophagosome biogenesis and regulation; the role of autophagy in
protein quality control; the role of autophagy in apoptosis;
autophagy in the cardiovascular system; and the relationships
between autophagy and lifestyle. Volume 8: Autophagy and Human
Diseases. Reviews recent advancements in the molecular mechanisms
underlying a large number of genetic and epigenetic diseases and
abnormalities, and introduces new, more effective therapeutic
strategies, in the development of targeted drugs and programmed
cell death, providing information that will aid on preventing
detrimental inflammation. Volume 9: Necrosis and Inflammation in
Human Diseases. Emphasizes the role of Autophagy in necrosis and
inflammation, explaining in detail the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of Omegasomes to autophagosomes.
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