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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Oxyradicals in Medical Biology, Volume 25 (Hardcover)
Loot Price: R2,691
Discovery Miles 26 910
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Oxyradicals in Medical Biology, Volume 25 (Hardcover)
Series: Advances in Molecular & Cell Biology
Expected to ship within 12 - 17 working days
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The rapid expansion of the area of free radical biology in the last
25 years has occurred within a framework of assumptions and
preconceived notions that has at times directed the course of this
movement. The most dominant of these notions has been the view that
free radical production is without exception a bad thing, and that
the more efficient our elimination of these toxic substances, the
better off we will be. The very important observation by Bernard
Babior and colleagues in 1973 that activated phagocytes produce
superoxide in order to kill micro organisms, served to illustrate
that constructive roles are possible for free radicals. For many in
the field, however, this merely underscored the deadly nature of
oxygen-derived radicals, both from the microbe's point of view and
from the host's as well. (Phagocyte-produced superoxide is
responsible in part for the tissue injury manifested as
inflammation. See Harris and Granger, Chapter 5, and Leff,
Hybertson and Repine, Chapter 6.)
Mother Nature, however, has a penchant for being able to make a
silk purse from a sow's ear. If one is dealt a bad hand, one must
simply make the best of it. After two decades of focusing on the
destructive side of free radicals, the last few years have begun to
reveal a new and finer perspective on free radical metabolism - a
role in regulation of cellular function (see Schulze-Osthoff and
Baeuerle, Chapter 2). Evidence from a number of sources suggests
that an increase in the oxidative status of cell encourages that
cell to grow and divide. Increasing the expression of mangnese
superoxide dismutase can suppress the malignant phenotype of
melanon cells (see Oberley and Oberley, Chapter 3). Oxidative
stress beyond a certain poitosis (from the Greek, literally "to
fall apart"). Is this suicide response an evolutionary fail-safe
device to curtail tumorogenesis? Does oxidative stress-induced
apoptosis account for the loss of immune cells in AIDS (see Flores
and McCor Chapter 4)?
This volume attempts to present the spectrum of roles, both good
and bad played by active oxygen species as understood at this point
in the evolution of this field of free radical biology.
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