Human chorionic gonadotropin (hCG) is produced during pregnancy by
the embryo. It promotes progesterone production by corpus luteal
cells. It also functions in pregnancy to promote angiogenesis in
uterine vasculature, it immuno-blands the invading placental tissue
so it is not rejected by the maternal uterine tissues, promotes the
growth of the uterus in line with the growth of the fetus, promotes
the differentiation of growing cytotrophoblast cells, promotes the
quiescence of contractions in the uterine myometrium during the
course of pregnancy, and also has function in growth and
development of fetal organs. The first edition described the
detailed biology, clinical chemistry, and clinical perspectives of
hCG and associated molecules, and examines hCG, hyperglycosylated
hCG and hCG free ss-subunit, 3 separate and independent molecules
with totally sovereign physiological functions. The second edition
will include coverage of the many new discoveries that have been
made in the last five years: hCG analogues may be the actual
driving signal of all human cancers. The editor estimates that 40%
of the out of date material will be excluded and replaced with 40%
of the exciting new findings. The book will also have a much
clearer pregnancy and cancer focus.
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