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Books > Medicine > Clinical & internal medicine > Hepatology
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Autoimmune Liver Diseases - Perspectives from Japan (Hardcover, 2014 ed.)
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Autoimmune Liver Diseases - Perspectives from Japan (Hardcover, 2014 ed.)
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Autoimmune Liver Diseases summarizes the recent high-impact
research and clinical findings obtained in Japan in the study and
treatment of autoimmune liver diseases. Although these disorders
are relatively rare, they are recognized as an important group of
refractory liver diseases, the most common of which are autoimmune
hepatitis (AIH) and primary biliary cirrhosis (PBC). The book
therefore comprises two major sections, one dealing with AIH, the
other with PBC. AIH in Japanese patients creates a unique disease
population, as its clinical features are different from those of
Western patients resulting from the different genetic background of
the two patient populations. Also, mouse models of neonatal
thymectomy-PD-1 knockout mice, clinical analyses of acute
hepatitis-like manifestations, and research findings on
IgG4-related autoimmune hepatitis have been reported in Japan and
are included in this book. A disease-susceptibility gene specific
to Japanese PBC patients has also recently been discovered. Because
of the relatively homogeneous population of Japan, analyses
conducted with Japanese PBC patients have yielded findings that are
highly relevant to the pathogenesis of the disease. Furthermore,
new pathological staging criteria, anti-gp210 antibodies and the
basis they provide for improved accuracy of prognosis, treatment
with bezafibrate, and the outcomes of living-donor liver
transplantation are also presented here. This volume therefore
serves as a useful resource not only for hepatologists, but also
for researchers, clinical residents, and medical students both in
Japan and in other countries.
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