Recently there have been many advances in the understanding of the
genetic basis of development and regular breakthroughs are being
made in the field of tumour cell targeting. Both these areas of
research are coming together in terms of their perception of
programmed cell death. A broad introduction of the biological
significance of cell death is followed by a major review of the
significance of physiological cell death in tumours and the factors
that influence it. The volume includes a consideration of the role
and functions of lymphokines and their bearing on tumour cell
targeting and cell killing. The interleukins, interferons and
tumour necrotic factor (TNF) are presented in terms of their
functional significance rather than in a sequential or systematic
manner. This volume concentrates on the bases of biological or
programmed cell death. Aspects of necrosis are, however, of
necessity covered in comparative and technical terms. The central
section on cell death in tumours is followed by a resume of the
techniques employed in demonstrating cell death and this section
closes with an appendix giving practical details of selected
methods. It is hoped that the book may help potential research
workers focus not only on the underlying molecular biology of
programmed cell death but also provide impetus for the development
of appropriate therapeutic regimes in tumour research.
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