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Books > Medicine > Clinical & internal medicine > Ophthalmology
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The Cornea in Normal Condition and in Groenouw's Macular Dystrophy (Paperback, Softcover reprint of the original 1st ed. 1980)
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Discovery Miles 14 970
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The Cornea in Normal Condition and in Groenouw's Macular Dystrophy (Paperback, Softcover reprint of the original 1st ed. 1980)
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The three most striking characteristics of the cornea are: a) Its
structure or rather its perfectly regular architectonic, by virtue
of which it is transparent. b) The absence of vessels, the cornea
being nourished by the perilimbic vessels, the endothelial surface
in communication with the aqueous humour and the epithelial surface
in contact with the pre-corneal film. c) The very slow turnover of
the cells, that is to say the keratocytes, with the result that the
metabolism of the cornea is very weak. It is this third
characteristic which justifies our present investigation. The
keratocytes, which are apparently inactive, have in fact a latent
activity. They can be activated by central corneal incisions and
also by tissue cultures. Under either of those conditions, the
keratocytes become very active, develop all the cytoplasmic
organites and produce mucopoly saccharides as well as the
precursors of the collagen (Fig. 1). In order to study the
pathological keratocyte, we chose a storage disease, wherein the
catabolism of the mucopolysaccharides is blocked, namely the
macular dystrophy of the cornea. We undertook the same
investigation both for normal and for pathologi cal corneas and
studied the keratocyte 'in situ' and in tissue cultures using
various microscopical and histochemical techniques. In macular
dystrophy, we investigated also the deteriorations secondary to the
changes in the keratocytes."
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