Despite the major developments in the therapeutic armamentarium for
the treatment of infection, the morbidity and mortality of this
complication remains very high in patients with compromised
defences. Cancer and its treatment represents a major predisposing
condition to a variety of infections. These adverse events are
still with us, in spite of much progress in the therapy of
infectious disease, since cancer therapy is becoming more
aggressive, yet further lowering the host's capacity to cope with
infections. Moreover, the pathogens adapt effectively to drugs, and
at a pace that might outrun industry's capability to produce new
agents. Finally, new pathogens are appearing as a consequence of
both selection and severe immunosuppression. Infection is so common
among cancer patients that its diagnosis and management represent a
daily challenge to all oncologists, who must continually strive to
keep abreast of developments in the area. The present comprehensive
review of the most crucial and challenging aspects of the
infectious complications in cancer patients will help them to do
just that.
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