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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Multidisciplinary Treatment of Soft Tissue Sarcomas (Paperback, Softcover reprint of the original 1st ed. 1993)
Loot Price: R5,552
Discovery Miles 55 520
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Multidisciplinary Treatment of Soft Tissue Sarcomas (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Cancer Treatment and Research, 67
Expected to ship within 10 - 15 working days
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The purpose of this book is to contribute to the further
development of the multidisciplinary approach to the treatment of
soft tissue sarcomas. A proper diagnosis and staging remains the
cornerstone of the treatment strategy. Sophisticated histopathology
techniques and growing consensus on grading systems have further
increased the importance of the histopathologist in providing
estimates of the prognosis of the patient as well as providing data
for the planning of treatment strategy. The use of cytogenetics is
relatively new in this field. This might enable distinction of
subgroups in specific histological tumor types. Further to this,
molecular biological studies not only help to reveal inherited
predispositions and details in oncogenesis in tumor development,
but they may also provide additional predictive factors for tumor
behaviour. Further data for the treament strategy will be provided
by diagnostic imaging, in which field the role of magnetic
resonance imaging is rapidly developing. As far as actual treatment
is concerned, surgery still provides the major chance for cure.In
view of the endeavour to be as sparing as possible, the addition of
radiotherapy to surgery is of utmost importance. Usually
radiotherapy is given after surgery, but the optimal sequence of
the two modalities yet needs to be defined. The combined use of
surgery with radiotherapy and/or chemotherapy does have an impact
on wound healing. A review on recent data concerning wound healing
in these situations has thus been added. There appears to be
growing consensus about the role of chemotherapy in metastatic
disease, where only doxorubicin, ifosfamide and DTIC are known to
be active. Although it may be different for subsets, in general,
single-agent chemotherapy appears to be as effecive as standard
doses of combination chemotherapy. The lack of efficacy of adjuvant
chemotherapy with standard doses of the drugs presently available
has been shown. Just as for radiotherapy, chemotherapy may have an
important role in the preoperative treatment of advanced soft
tissue sarcomas, where intravenous drug administration appears to
be as effective as the more complicated intraarterial
administration.Thermochemotherapy, another and still
investigational approach to advanced local disease, also yields
interesting preliminary results. Finally, clinical behaviour,
treatment strategy and the outcome of treatment in childhood soft
tissue sarcomas are quite different from those in adult soft tissue
sarcomas.
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