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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Biological Reactive Intermediates III - Mechanisms of Action in Animal Models and Human Disease (Paperback, Softcover reprint of the original 1st ed. 1986)
Loot Price: R3,173
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Biological Reactive Intermediates III - Mechanisms of Action in Animal Models and Human Disease (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: Advances in Experimental Medicine and Biology, 197
Expected to ship within 10 - 15 working days
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This volume contains the proceedings of the third in a series of
conferences entitled, The International Symposium on Biological
Reactive Intermediates. The first was held at the University of
Turku in Finland, in 1975, the second at the University of Surrey
in the United Kingdom, in 1980 and the most recent at the
University of Maryland in the United States, in 1985. The
significance of these conferences has been emphasized by the rapid
growth of mechanistic toxicology over the last decade. These
conferences were initially stimulated by the attempt to uncover the
significance behind the observations that the toxicity of
carcinogenic responses produced by many chemicals was associated
with the observation that their metabolism led to the formation of
chemcially reactive electrophiles which covalently bound to
nucleophilic sites in cells such as proteins, nucleic acid or fats.
Recently, newer concepts have arisen which have necessitated the
expansion of subjects covered by the conference. For example, the
application of newer knowledge of the role of active oxygen species
in reactive metabolite formation, the concept of suicide
substrates, examination of the function of glutathione in cells,
application of immunological techniques and molecular biological
probes to the solution of toxicological problems all had an impact
on the study of the biological reactive intermediates.
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