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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Cytochrome P450 Enzymes - Biochemistry, Pharmacology & Health Implications (Hardcover)
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Cytochrome P450 Enzymes - Biochemistry, Pharmacology & Health Implications (Hardcover)
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Cytochrome P450 (CYP) is a super family of phase I enzyme in the
biotransformation of xenobiotics and medications. Most medications
undergo deactivation by CYP, and then are eliminated through either
bile or kidneys from the body. CYP isozymes play a crucial role in
drug interactions that may result in enhanced toxicity, reduced
efficacy or onset of adverse reactions. On the other hand, many
agents affecting CYP expression and activity may alter metabolic
rate of different medications co-administrated. Therefore, the
molecular basis, regulation by inducers or inhibitors, and
pharmacologic reaction of specific CYP isozymes are the key issues
of biochemical mechanisms, pharmaceutical development and safe use
of various medications. This book is to meet the needs from basic
molecular biochemists, pharmacologists, pharmacists, medical
students, clinical practitioners and scientists, as well as broad
readers who wish to understand how an herbal extract, medication or
natural supplement is metabolized or transformed in the liver or
other sites for deactivation and elimination. Special focuses are
paid to herbal extracts and medications in the treatment of
neuro-psychiatric or cardiovascular disorders, diabetes and viral
hepatitis. Detailed dissection of drug interactions in a particular
field intends to provide rationales for useful guidance of safe
drug use in daily practice. The contributing authors are basic
scientists, pharmacists, pharmacologists and on-service physicians
in cardiovascular, neuro-psychiatric, gastroenterologic and
hepatologic fields from Europe (Germany, France, Portugal),
Australia, the US and China. Thus, the book is the collection of
master pieces by well-known experts from various regions of the
world, and represents the current understanding of CYP enzyme
reaction and a contemporary coverage of possible drug interactions
in involved fields. The featured chapters are scientific
elucidation of basic biochemistry, pharmacology and clinical
investigations in the interest of drug metabolism, interaction and
safe use guidance in the single focus of this microsomal enzyme
with multi-facet metabolic function.
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