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Hormonal Carcinogenesis - Proceedings of the First International Symposium (Paperback, Softcover reprint of the original 1st ed. 1992)
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Hormonal Carcinogenesis - Proceedings of the First International Symposium (Paperback, Softcover reprint of the original 1st ed. 1992)
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In the past decade there has been a growing public interest and
resurgence in research in the field of hormonal carcinogenesis.
This is due to the widespread use of therapeutic hormonal agents
worldwide and to the increasing awareness of the causal association
of hormones, both endogenous and exogenously administered, and a
variety of human cancers. These associations include estrogens in
uterine, cervical, vaginal, liver, testicular, prostatic, and
possible breast cancers; progesterone and progestational hormones
in breast cancer; androgens and anabolic steroids in hepatic and
prostatic cancers. Additionally, gonadotrophins playa role in the
etiology of ovarian and testicular cancers and thyroid-stimulating
hormones in thyroid cancers. Therefore, hormonal carcinogenesis
encompasses the study of both natural and synthetic hormonal
agents, including growth factors and other peptide and protein
factors, which contribute substantially to the etiology of both
human and animal neoplasms, benign or malignant. Hormones may be
involved in all aspects of neoplastic transformation, including
initiation, promotion, and progression, and the inhibition of these
processes. There are a number of important issues in women's health
that need to be addressed. More than 40 million U. S. women are
menopausal, and these women have a life expectancy of over 30 years
after the menopause. When these figures are multiplied worldwide,
the numbers become staggering. After the menopause, estrogen
replacement therapy (ERT) is the choice of most women in
industrialized countries.
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