Basic research discusses the implication of pancreatic stress
protein in acute pancreatitis and pancreatic cancer and their
possible role as therapeutic targets. Also, very original results
show the unexpected role of lipids as mediators during acute
pancreatitis. Gene screening strategies allow the detection of the
genes responsbile for gemcitabine resistance of pancreatic cancer
cells. They lead to the selection of several target genes, in order
to suppress the resistance of cells to gemcitabine treatment. The
mechanism by which tetrahydrocannabinol is anti-tumoral in
pancreatic cancer cells is presented and the use of THC as a
promising new therapeutic agent is discussed.
Genetic data are shown concerning hundreds of families with
hereditary chronic pancreatitis and their possible role in the
pathogenesis of the disease. Another very original study addresses
the prevention and treatment of pancreatic diseases with diat.
In clinical research, convincing data about the use of
endoscopic sphicterotomy in the management of acute bilary
pancreatitis is presented, based on the experience of a Center
highly specialized in pancreatic diseases.
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