In 1890, just a few years after the discovery of the chromosomes,
David Paul Hansemann, a pathologist-in-training with the famous
Rudolph Virchow in Berlin, produced a theory of the pathogenesis of
cancer involving the key current concept: that the first change
which occurs in cancer is an alteration of the hereditary material
of a normal cell at the site where the cancerous process begins.
In the process of linking cancer to chromosomal material,
Hansemann coined the terms "anaplasia" and "dedifferentiation."
These terms have remained the basis of descriptive terms concerning
the microscopical appearances of tumours ever since. Nevertheless,
despite the popularity of his terminology, Hansemann's ideas were
attacked vigorously by almost all proponents of rival theories of
the nature of cancer. Partly due to these disputes during his
life-time, and partly due to other factors, interest in von
Hansemann's ideas diminished during the twentieth century and his
works are rarely mentioned today.
This book presents translations of all the relevant German
texts, and analyses the background and context of Hansemann's
theories as well as the reasons why he was almost completely
forgotten. It shows that some of Hansemanna (TM)s ideas may still
be relevant to cancer research today, and that he deserves to be
remembered in relation to cancer as Vordenker unter den
fA1/4hrenden Denkern seiner Zeit - The foremost of the leading
thinkers of his time.
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