Rabbit Biotechnology - Rabbit genomics, transgenesis, cloning and models (Hardcover, 2009 ed.)

Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.

General

Imprint:	Springer
Country of origin:	Netherlands
Release date:	May 2009
First published:	2009
Editors:	Louis Marie Houdebine • Jianglin Fan
Dimensions:	235 x 155 x 9mm (L x W x T)
Format:	Hardcover
Pages:	136
Edition:	2009 ed.
ISBN-13:	978-90-481-2226-4
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Professional & Technical > Biochemical engineering > Biotechnology > Genetic engineering
LSN:	90-481-2226-0
Barcode:	9789048122264

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