Paraoxonase (PON1) in Health and Disease - Basic and Clinical Aspects (Paperback, Softcover reprint of the original 1st ed. 2002)

The paraoxonase or PON family of genes resides on human chromosome 7q2t-22 in the order PONt, PON3 and PON2. PONt was one of the early genes identified as an environmentally relevant gene, in that it is important in determining an individual's sensitivity or resistance to exposure from specific organophosphorus (OP) insecticides. Paraoxonase (PONt) is an A esterase (i. e., not inhibited by OP compounds) initially identified for its ability to catalytically hydrolyze paraoxon, the toxic metabolite (oxon form) of the insecticide parathion. Evidence accumulated in the past several years has established that this enzyme, which is present at variable levels in liver and serum of different individuals, is an important determinant of sensitivity to toxicity of specific organophosphorus compounds including chlorpyrifos oxon and diazoxon. Recent experiments have pointed out that it is the catalytic efficiency of PONt together with the levels of PONt that are important in determining the degree of resistance. Surprisingly, even though PONt has a higher catalytic efficiency than PONtQ)92 for paraoxon RJ92 hydrolysis, it does not provide significant in vivo protection against an exposure to paraoxon. Interest in this enzyme has also emerged from the finding that it displays genetic polymorphisms in most populations, with a significant number of the individuals in a given population canying a PONt gene that puts them at risk for a specific OP exposure."

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	March 2013
First published:	2002
Editors:	Lucio G. Costa • Clement E. Furlong
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	216
Edition:	Softcover reprint of the original 1st ed. 2002
ISBN-13:	978-1-4613-5358-4
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Professional & Technical > Environmental engineering & technology > General Books > Medicine > General issues > Public health & preventive medicine > General Books > Medicine > Other branches of medicine > Pharmacology > General Promotions
LSN:	1-4613-5358-0
Barcode:	9781461353584

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