Recent years have witnessed dramatic advances in the development
and use of magnetic resonance imaging (MRI) techniques that can
provide quantitative measures with some degree of pathological
specificity for the heterogeneous substrates of multiple sclerosis
(MS). Magnetic resonance spectroscopy (MRS) is one of the most
promising of these techniques. Thanks to MRS, axonal damage is no
longer considered an end-stage phenomenon typical of only the most
destructive lesions and the most unfortunate cases, but rather as a
major component of the MS pathology of lesions and normal-appearing
white matter at all the phases of the disease. This new concept is
rapidly changing our understanding of MS pathophysiology and, as a
consequence, the therapeutic strategies to modify the disease
course favorably. Many of the authors have pionereed the use of MRS
in MS, thus contributing to the foundation of the "axonal
hypothesis."
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