Regulatory Mechanisms in Breast Cancer - Advances in Cellular and Molecular Biology of Breast Cancer (Paperback, Softcover reprint of the original 1st ed. 1991)

In Breast Cancer: Cellular and Molecular Biology Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression."

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Cancer Treatment and Research, 53
Release date:	October 2012
First published:	1991
Editors:	Marc E. Lippman • Robert B. Dickson
Dimensions:	235 x 155 x 24mm (L x W x T)
Format:	Paperback
Pages:	452
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-1-4613-6758-1
Categories:	Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-4613-6758-1
Barcode:	9781461367581

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