The history of developmental biology is interwoven with debates as
to whether mechanistic explanations of development are possible or
whether alternative explanatory principles or even vital forces
need to be assumed. In particular, the demonstrated ability of
embryonic cells to tune their developmental fate precisely to their
relative position and the overall size of the embryo was once
thought to be inexplicable in mechanistic terms. Taking a causal
perspective, this Element examines to what extent and how
developmental biology, having turned molecular about four decades
ago, has been able to meet the vitalist challenge. It focuses not
only on the nature of explanations but also on the usefulness of
causal knowledge - including the knowledge of classical
experimental embryology - for further scientific discovery. It also
shows how this causal perspective allows us to understand the
nature and significance of some key concepts, including organizer,
signal and morphogen. This title is also available as Open Access
on Cambridge Core.
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