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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
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Chemical Toxicity Prediction - Category Formation and Read-Across (Hardcover)
Loot Price: R3,779
Discovery Miles 37 790
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Chemical Toxicity Prediction - Category Formation and Read-Across (Hardcover)
Series: Issues in Toxicology, Volume 17
Expected to ship within 12 - 17 working days
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The aim of this book is to provide the scientific background to
using the formation of chemical categories, or groups, of molecules
to allow for read-across i.e. the prediction of toxicity from
chemical structure. It covers the scientific basis for this
approach to toxicity prediction including the methods to group
compounds (structural analogues and / or similarity, mechanism of
action) and the tools to achieve this. The approaches to perform
read-across within a chemical category are also described. The book
will provide concise practical guidance for those wishing to apply
these methods (in risk / hazard assessment) and will be illustrated
with case studies. Chemical Toxicity Prediction is the first book
that addresses the concept of category formation and read-across
for toxicity prediction specifically. This topic has really taken
off in the past few years due to concerns over dealing with the
REACH legislation and also due to the availability of the OECD
(Q)SAR Toolbox. Much (lengthy and complex) guidance is available on
category formation e.g. from the OECD and, to a lesser extent, the
European Chemicals Agency but there is no one single source of
information that covers all techniques in a concise user-friendly
format. There is a real need for this information as in silico
toxicology has come to the fore in recent years, primarily as a
result of the EU REACH legislation, but also due to many other
drivers e.g. reduction of animal testing, Cosmetics regulation.
Category formation is seen as the only practical approach to make
rational and transparent predictions for complex (human)
toxicological endpoints. The book covers all the areas required to
create a robust category and perform read-across.
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