Expert bench and clinical scientists join forces to concurrently
review both the state-of-the-art in tumor immunology and its
clinical translation into promising practical treatments. The
authors explain in each chapter the scientific basis behind such
therapeutic agents as monoclonal antibodies, cytokines, vaccines,
and T-cells, and illustrate their clinical manipulation to combat
cancer. Additional chapters address statistical analysis-both of
clinical trials and assay evaluations-methods for the discovery of
antigens, adoptive T cell therapy, and adaptive and innate
immunity. The challenges in clinical trial design, the need for
biomarkers of response-such as novel imaging techniques and
immunologic monitoring-and the new advances and directions in
cancer immunotherapy are also fully examined.
General
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