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Diet and Cancer - Markers, Prevention, and Treatment (Hardcover, 1994 ed.)
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Diet and Cancer - Markers, Prevention, and Treatment (Hardcover, 1994 ed.)
Series: Advances in Experimental Medicine and Biology, 375
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The American Institute for Cancer Research (AICR) sponsored its
third annual confer ence on nutrition and cancer. The theme was
"Diet and Cancer: Markers, Prevention, and Treatment. " The
conference was held October 29-30, 1992 at the Ritz Carlton Hotel
in McLean, Virginia. This proceedings contains chapters from the
platform presentations and abstracts from the poster presentations.
Several chapters address each of four session topics: Retinoids as
Differentiation Agents in Cancer Therapy, Biological Markers of
Cancer Risk, Chemoprevention of Cancer by Non-Nutrients in Foods,
and Nutritional Problems and Support in the Treatment of Cancer.
The first three chapters discuss in detail different mechanisms by
which retinoids influence differentiation and provide evidence to
support their use in cancer therapy. In vivo and in vitro studies
show the effects of retinoic acid (RA) on tumorigenicity and cellu
lar/molecular events. A synopsis of data showing the involvement of
the retinoblastoma (RB) gene in HL-60 cell differentiation induced
by RA and 1,2S-dihydroxy vitamin D3 (VD) is presented. In SCID
(severe combined immunodeficiency) mice injected with HL-60 3 human
leukemia cells and gavaged daily with RA, the number of tumor sites
and number of mice with tumors are reduced. All trans-RA induces
myeloid differentiation in HL-60 cells. Similarly, VD3 induces
HL-60 monocytic differentiation. In both cases an early down
regulation of retinoblastoma (RB) gene expression precedes the
differentiation."
General
Imprint: |
Kluwer Academic / Plenum Publishers
|
Country of origin: |
United States |
Series: |
Advances in Experimental Medicine and Biology, 375 |
Release date: |
2001 |
First published: |
1994 |
Editors: |
Maryce M. Jacobs
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Dimensions: |
254 x 178 x 18mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
256 |
Edition: |
1994 ed. |
ISBN-13: |
978-0-306-44723-5 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Diseases & disorders >
Oncology >
General
|
LSN: |
0-306-44723-1 |
Barcode: |
9780306447235 |
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