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Ranaviruses - Lethal Pathogens of Ectothermic Vertebrates (Hardcover, 2015 ed.)
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Ranaviruses - Lethal Pathogens of Ectothermic Vertebrates (Hardcover, 2015 ed.)
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This is the first book on ranaviruses. Ranaviruses are
double-stranded DNA viruses that cause hemorrhagic disease in
amphibians, reptiles, and fish. They have caused mass die-offs of
ectothermic vertebrates in wild and captive populations around the
globe. There is evidence that this pathogen is emerging and
responsible for population declines in certain locations.
Considering that amphibians and freshwater turtles are suitable
hosts and the most imperiled vertebrate taxa in the world,
ranaviruses can have significant impacts on biodiversity and
ecosystem function. Additionally, many fish that are raised in
aquaculture facilities and traded internationally are suitable
hosts; thus, the potential economic impact of ranaviruses is
significant. Ranaviruses also serve as a model for replication and
gene function of large double-stranded DNA viruses. There is an
urgent need to assemble the contemporary information on ranaviruses
and provide guidance on how to assess their threats in populations.
Through the Global Ranavirus Consortium, 24 experts from six
countries were organize to write this volume, the first book on
ranaviruses. The book begins with a discussion on the global extent
of ranaviruses, case histories of infection and disease in
ectothermic vertebrates, and current phylogeny. Basic principles of
ranavirus ecology and evolution are covered next, with a focus on
host-pathogen interactions and how the virus emerges in its
environment. There are two chapters that will discuss the molecular
biology of ranaviruses, host response to infection, and the genes
responsible for immune system evasion. One chapter establishes
standards for testing for infection and diagnosing ranaviral
disease. The book ends by providing guidance on how to design
ranavirus surveillance studies and analyze data to determine risk,
and discussing the role of the Global Ranavirus Consortium in
organizing research and outreach activities.
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