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Multiple Risk Factors in Cardiovascular Disease (Paperback, Softcover reprint of the original 1st ed. 1992)
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Multiple Risk Factors in Cardiovascular Disease (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Medical Science Symposia Series, 1
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This book includes the most significant contributions of the First
International Symposium on "Multiple risk factors in cardiovascular
disease", chaired by Professors A. V. Chobanian (Boston), A. M.
Gotto Jr. (Houston), c. Lenfant (Bethesda), R. Paoletti and A.
Zanchetti (Milan), held in Washington DC, 10-12 December 1990,
which focused on the risk factors for cardiovascular disease and
their interactions. The need for this symposium is based on the
epidemiological evidence that individuals from industrialized
countries often possess two or more risk factors which synergically
increase the global risk profile. The evidence that isolated
vascular risk factors are not commonly found in high risk patients
but more often a combination of risk factors are detected, is
highlighted. Many recent epidemiological data identifying the
intrinsic and environ mental factors contributing to the
development of atherosclerosis are discussed. These results, in
parallel to basic and clinical research, underline how
atherosclerosis is a complex and multifac torial process involving
the influences of lipid deposition, blood pressure, rheologic
forces, carbohydrate tolerance, and thrombogenic factors
(fibrinogen and platelets). Atherosclerosis is markedly accelerated
by other risk factors, more so in the presence of concomitant
hypercholes terolemia, hypertension, diabetes, upper body obesity.
Furthermore, the risk associated with anyone of these risk factors
varies widely depending on level of the associated atherogenic risk
factors.
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