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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Molecular Genetics of Inflammatory Bowel Disease (Hardcover, 2013 ed.)
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Molecular Genetics of Inflammatory Bowel Disease (Hardcover, 2013 ed.)
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Research in Crohn's disease (CD) and ulcerative colitis (UC),
together known as the inflammatory bowel diseases (IBD), has truly
seen a revolution in the last 5-10 years. This book examines how
these genetic discoveries have led to the identification of
biological functions not previously associated with IBD
pathophysiology (e.g. autophagy), how multiple genetic risk factors
for IBD converge on given biological functions and that together
the identified variants in these genes have predisposing and
protective roles (e.g. the multiple variants in the receptor for
the IL23 cytokine and its signaling cascade), and how having such a
large number of known genetic risk factors has changed our
understanding not only about the genetic and molecular overlap
between CD and UC, but also between these diseases and other
chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis,
type 1 diabetes and many others).
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