Thirty per cent of all women and ten per cent of all men experience
migraine. This crippling illness does not kill, but its high
morbidity poses a massive economic problem and gives rise to
considerable suffering. Its main manifestation, headache, is
subjective, and there are no animal models. This makes traditional
research approaches difficult, and has led to a variety of research
strategies. In this study, leaders in migraine research present the
numerous advances that have been made over the past two decades in
our understanding of this disorder, and discuss in depth the
position of migraine research today and the directions it will take
in the future.
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