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The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease (Hardcover, 2003 ed.)
Loot Price: R2,992
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The Sodium-Hydrogen Exchanger - From Molecule to its Role in Disease (Hardcover, 2003 ed.)
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I am extremely honored and pleased to have the opportunity to write
a few introductory words for this timely volume on Na + /It
exchange. This is a field of investigation that I entered into by
challenge and necessity, embraced with passion and fmally left in
my quest for new discoveries in growth control. Ten years, one
third of my scientific life, has been devoted to uncovering the
mysteries of intracellular pH (PH;) regulation with respect to
growth factor action. I got started on this new topic in 1980, when
I heard a rather provocative hypothesis presented by Enrique
Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and
Malignancy." He showed that all mitogens induced
amiloride-sensitive Na + entry into resting cells and proposed
that, if a compound stimulates Na + influx, it could be a mitogen.
In support of his proposal Enrique reported that the amphipathic
polypeptide, mellitin, which induced Na+ influx, was indeed
mitogenic for 3T3 cells. This was only correlation at this stage.
However, I was fascinated by this talk. I immediately approached
Enrique to inform him of my skepticism about this beautiful story,
and to indicate that I would only be convinced when I succeeded in
isolating mutant fibroblasts lacking the amiloride-sensitive Na+
transporter. ''Good luck " was his response.
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