Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Target Discovery and Validation Reviews and Protocols - Emerging Strategies for Targets and Biomarker Discovery, Volume 1 (Paperback, Softcover reprint of hardcover 1st ed. 2007)
Loot Price: R3,046
Discovery Miles 30 460
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Target Discovery and Validation Reviews and Protocols - Emerging Strategies for Targets and Biomarker Discovery, Volume 1 (Paperback, Softcover reprint of hardcover 1st ed. 2007)
Series: Methods in Molecular Biology, 360
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Total price: R3,066
Discovery Miles: 30 660
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Target discovery is a field that has existed for several years but
is so vibrant today because of the recent progress in our
understanding of the molecular mechanisms of many human diseases
and the technical advances in target identification and validation.
More sophisticated gene profiling technologies, such as DNA
microarrays and serial analysis of gene expression, permit rapid
identification of lead targets. Moreover, analysis of gene networks
in living organisms allows the identification of target genes that
operate in defined physiological pathways. With the sequencing of
several genomes completed and the rapidly growing gene expression
databases, there is now greater impetus than ever before for in
silico discovery of therapeutic targets. Also, recent advances in
genetic technologies have increased our ability to generate mouse
models for human diseases. The implications of these genetically
modified animals in drug development are several, including
identification of new drug targets, predicting efficacy, and
uncovering possible side effects. Together, these recent technical
advances should allow researchers to make the most informed choice
early and advance the chosen targets toward clinical studies.
Regarding cancers, any difference between a cancer and a normal
cell could potentially be exploited as a therapeutic target. The
hope is that drugs targeting specific constituents or pathways in
cancer cells will provide more effective therapy, either alone or
in combination with other currently used anticancer drugs. In
addition to drug targets, identifying new target antigens remains
as much of a challenge as improving tumor vaccines already in the
clinic.
General
Imprint: |
HumanaPress
|
Country of origin: |
United States |
Series: |
Methods in Molecular Biology, 360 |
Release date: |
November 2010 |
First published: |
2007 |
Editors: |
Mouldy Sioud
|
Dimensions: |
229 x 152 x 20mm (L x W x T) |
Format: |
Paperback
|
Pages: |
354 |
Edition: |
Softcover reprint of hardcover 1st ed. 2007 |
ISBN-13: |
978-1-61737-699-3 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Diseases & disorders >
Oncology >
General
|
LSN: |
1-61737-699-X |
Barcode: |
9781617376993 |
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