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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
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A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment (Hardcover, 1st ed. 2018)
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A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment (Hardcover, 1st ed. 2018)
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Social pressure to minimize the use of animal testing, the
ever-increasing concern on animal welfare, and the need for more
human-relevant and more predictive toxicity tests are some of the
drivers for new approaches to chemical screening. This book focuses
on The Adverse Outcome Pathway, an analytical construct that
describes a sequential chain of causally linked events at different
levels of biological organization that lead to an adverse health or
ecotoxicological effect. While past efforts have focused on
toxicological pathway-based vision for human and ecological health
assessment relying on in vitro systems and predictive models, The
Adverse Outcome Pathway framework provides a simplified and
structured way to organize toxicological information. Within the
book, a systems biology approach supplies the tools to infer, link,
and quantify the molecular initiating events and the key events and
key event relationships leading to adverse outcomes. The
advancement of these tools is crucial for the successful
implementation of AOPs for regulatory purposes.
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