Purine Metabolism in Man - Biochemistry and Pharmacology of Uric Acid Metabolism (Paperback, Softcover reprint of the original 1st ed. 1974)

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication."

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 41
Release date:	April 2013
First published:	1974
Editors:	Oded Sperling
Dimensions:	235 x 155 x 26mm (L x W x T)
Format:	Paperback
Pages:	476
Edition:	Softcover reprint of the original 1st ed. 1974
ISBN-13:	978-1-4757-1435-7
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Promotions
LSN:	1-4757-1435-1
Barcode:	9781475714357

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