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Endocrinology and Physiology of Reproduction (Paperback, Softcover reprint of the original 1st ed. 1987)
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Endocrinology and Physiology of Reproduction (Paperback, Softcover reprint of the original 1st ed. 1987)
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Most of the following chapters were presented as plenary lectures
or symposium talks at the 1986 XXXth Congress of the International
Union of Physiological Sciences in Vancouver, B.C. A distinguished
international group of endocrinologists and physiologists have
contributed up-to-date reviews of their particular fields. The
early chapters are largely concerned with the brain and
neuroendocrine mechanisms controlling the secretion of gonadotropin
releasing hormone (GnRH) and its action on the anterior pitui- tary
gland. Later chapters focus on the gonads themselves and the
systemic and intrinsic hormones influencing the functional cytology
of ovarian and testicular cells. Such comprehensive subjects as sex
differentiation, puberty, placentation and parturition are also
discussed authoritatively. According to Pfaff and Cohen and Arai et
al., gonadal steroids, especially estrogen, exert multiple effects
on certain hypothalamic and preoptic neurons, including growth,
protein synthesis and electrical changes, which promote plasticity
and facilitate synaptogenesis. The electrophysio- logy of the
hypothalamic GnRH pulse generator in the rhesus monkey is reviewed
more specifically by Knobil. In ovariectomized ewes, Clarke finds
both positive and negative effects of estrogen on hypothalamic
release of GnRH as well as on pituitary responsiveness to the
peptide. Flerk6 et al.
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