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Analogues of Nucleic Acid Components - Mechanisms of Action (Paperback, Softcover reprint of the original 1st ed. 1970)
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Analogues of Nucleic Acid Components - Mechanisms of Action (Paperback, Softcover reprint of the original 1st ed. 1970)
Series: Recent Results in Cancer Research, 25
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The rationale for the design of structural analogues of a normal
metabolite is that such compounds may interfere in the utilization
or function of the metabolite. A compound which is effective in
this respect may be called an antimetabolite. To be successful in
chemotherapy of bacterial, viral, or tumor growth, an
antimetabolite should adversely affect some vital metabolic
reactions in the parasite or parasitic tissue without seriously
endangering the host tissue. If a metabolic process of the
offending growth is different from that of the host, it is likely
that the metabolism or activity of a compound, structurally related
to a metabolite involved in that process, will also be different in
these cells. Such differences are useful for devising effective
drugs with selective actions. Sulfanilamide, a structural analogue
of para aminobenzoic acid, interferes with the utilization of this
metabolite in the synthesis of folic acid, an essential factor for
growth. Bacteria synthesize their own folic acid and are incapable
of utilizing exogenously available folic acid. However, the
situation is exactly opposite in the animal host. That is, animal
tissues cannot synthesize folic acid and are absolutely dependent
upon exogenous sources. These differences in metabolism make
possible the use of sulfanilamide as a selective inhibitor of
growth. Other antibacterial or antiparasitic drugs, such as
penicillin (BURCHALL, FERONE and HITCHINGS, 1965) and inhibitors of
dihydrofolate reductase (HITCHINGS and BURCHALL, 1965; HITCHINGS,
1964; BURCHALL and HITCHINGS, 1965) have analogous desirable
selective toxicity effects."
General
Imprint: |
Springer-Verlag
|
Country of origin: |
Germany |
Series: |
Recent Results in Cancer Research, 25 |
Release date: |
April 2012 |
First published: |
1970 |
Authors: |
P Roy-Burman
|
Dimensions: |
244 x 170 x 6mm (L x W x T) |
Format: |
Paperback
|
Pages: |
114 |
Edition: |
Softcover reprint of the original 1st ed. 1970 |
ISBN-13: |
978-3-642-85578-8 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-642-85578-4 |
Barcode: |
9783642855788 |
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