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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Next Generation Kinase Inhibitors - Moving Beyond the ATP Binding/Catalytic Sites (Hardcover, 1st ed. 2020)
Loot Price: R3,810
Discovery Miles 38 100
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Next Generation Kinase Inhibitors - Moving Beyond the ATP Binding/Catalytic Sites (Hardcover, 1st ed. 2020)
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Protein kinases are fascinating enzymes that maintain the proper
function of nearly every task performed by the cells of the human
body. By extracting a phosphate from the energy molecule ATP and
linking it to another protein, protein kinases alter the structure
and ultimate function of other proteins. In this way, protein
kinases help monitor the extracellular environment and integrate
signaling cues that, for the most part, are beneficial for human
health and survival. However, protein kinases are often
dysregulated and responsible for the initiation and progression of
many types of cancers, inflammatory disorders, and other diseases.
Thus, decades of research have revealed much about how protein
kinases are regulated and approaches to inhibit these enzymes to
treat disease. However, nearly 30 years since the identification of
the first clinically beneficial small molecule protein kinase
inhibitor, there are only a few examples where these drugs provide
sustained and durable patient responses. The goal of this book is
to provide biomedical scientists, graduate, and professional degree
students insight into different approaches using small molecules to
block specific protein kinase functions that promote disease.
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