Over two centuries ago, oxygen was discovered as "air vital" the
component of the earth's atmosphere necessary for life. Less than
five years after this discovery, it was found that oxygen was both
a life-sustaining and life threatening inhalant as it plays a role
in the two extremes of the animal kingdom: life and death. In the
subse quent years, we have made major strides in understanding the
role of oxygen in maintaining life and volumes of information are
now available on this topic. Our knowledge of the contribution of
oxygen in cellular dysfunction and cell death which for the most
part had lagged behind has begun to catch up. The deleterious ef
fects of oxygen radicals and activated oxygen species on a variety
of biological systems have now been described. Recently attention
has also been focused on the toxic effects of oxygen on the
cardiovascular system. The major aim of the present treatise is to
offer an integrated view of the pathophysiological aspects of
oxygen toxicity in the heart and blood vessels coupled with a
review of therapeutic approaches (hopes?) with free radical
scavengers and antioxidants. Internationally known expert
investigators provide a concise and critical review on the topic of
their expertise which also contains data from their own research."
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