This book provides a readable introduction to modern toxicology
with a particular focus on the mechanisms underlying the induction
of toxicity by foreign substances. Since bioactivation is central
to many toxic syndromes, special interest is devoted to chemicals
that undergo conversion to toxic metabolites that induce toxic
effects as diverse as cancer, birth defects and organ injury. The
molecular consequences accompanying damage to cellular DNA and
proteins is explored together with the relevance of toxicological
paradigms to human diseases caused by alcohol and tobacco. The
discipline of toxicology has developed rapidly since the
thalidomide disaster in the 1960's as scientists worldwide seek to
understand the adverse health effects of human medicines,
environmental pollutants, consumer chemicals and industrial
reagents. An Introduction to Toxicology is intended to supplement
the recommended reading list of undergraduate and graduate programs
in toxicology and pharmacology as an enjoyable, accessible primer
with illustrations that "unpack" the concepts being discussed in
the text.
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